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Study · Animal study (in vivo) · rat · 2001

7 results

Oxytocin decreases carrageenan induced inflammation in rats.

Petersson M, Wiberg U, Lundeberg T, Uvnäs-Moberg K

Peptides1 Sept 2001Cited by 96 (Europe PMC)

PMID11514032 (opens in a new tab)DOI10.1016/s0196-9781(01)00469-7 (opens in a new tab)PepBankPUB-11514032
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with carrageenan-induced paw inflammation, subcutaneous oxytocin at 100 microg/kg reduced paw edema.

    In plain wordsIn rats with paw inflammation, oxytocin at 100 micrograms per kilogram reduced paw swelling.

    Peptide
    Oxytocin
    Outcome
    DecreasePaw edema at 100 microg/kg
    Study

    ratn: not reported in source

    Carrageenan-induced hindpaw inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    100 microg/kg · subcutaneousAs given in this study (rat).

    Measurements

    Dose
    100 microg/kg
    s.c.

    Source sentences

    Summary
    Oxytocin at 100 (P < 0.05) and 1000 microg/kg s.c. (P < 0.05), but not at 1 and 10 microg/kg s.c., reduced the edema of the paw when measured up to 10 h after the injection.
    1 context sentence
    Summary · context
    The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with carrageenan-induced paw inflammation, subcutaneous oxytocin at 1000 microg/kg reduced paw edema.

    In plain wordsIn rats with paw inflammation, oxytocin at 1000 micrograms per kilogram reduced paw swelling.

    Peptide
    Oxytocin
    Outcome
    DecreasePaw edema at 1000 microg/kg
    Study

    ratn: not reported in source

    Carrageenan-induced hindpaw inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1000 microg/kg · subcutaneousAs given in this study (rat).

    Measurements

    Dose
    1000 microg/kg
    s.c.

    Source sentences

    Summary
    Oxytocin at 100 (P < 0.05) and 1000 microg/kg s.c. (P < 0.05), but not at 1 and 10 microg/kg s.c., reduced the edema of the paw when measured up to 10 h after the injection.
    1 context sentence
    Summary · context
    The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with carrageenan-induced paw inflammation, subcutaneous oxytocin at 1 and 10 microg/kg did not reduce paw edema.

    In plain wordsIn rats with paw inflammation, oxytocin at the two lowest doses did not reduce paw swelling.

    Peptide
    Oxytocin
    Outcome
    No significant changePaw edema at 1 and 10 microg/kg
    Study

    ratn: not reported in source

    Carrageenan-induced hindpaw inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1 and 10 microg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin at 100 (P < 0.05) and 1000 microg/kg s.c. (P < 0.05), but not at 1 and 10 microg/kg s.c., reduced the edema of the paw when measured up to 10 h after the injection.
    1 context sentence
    Summary · context
    The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with carrageenan-induced paw inflammation, the edema-reducing effect of oxytocin was comparable to that of dexamethasone.

    In plain wordsIn rats with paw inflammation, oxytocin reduced swelling about as much as the steroid dexamethasone.

    Peptide
    Oxytocin
    Outcome
    No significant changePaw edema compared with dexamethasone
    Study

    ratn: not reported in source

    Carrageenan-induced hindpaw inflammation
    Comparator
    Dexamethasone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An additional experiment showed that the effect was comparable to the effect of the glucocorticoid dexamethasone.
    1 context sentence
    Summary · context
    The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with carrageenan-induced paw inflammation, oxytocin given intracerebroventricularly had no effect.

    In plain wordsIn rats with paw inflammation, oxytocin injected into the brain ventricles had no effect.

    Peptide
    Oxytocin
    Outcome
    No significant changePaw edema after intracerebroventricular oxytocin
    Study

    ratn: not reported in source

    Carrageenan-induced hindpaw inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    No effect was found by oxytocin i.c.v.
    1 context sentence
    Summary · context
    The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with carrageenan-induced inflammation, oxytocin at 1000 microg/kg changed the response to nociceptive mechanical stimulation; the direction is not stated.

    In plain wordsIn rats with paw inflammation, oxytocin at 1000 micrograms per kilogram changed how the rats responded to a painful pressure test.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedResponse to nociceptive mechanical stimulation
    Study

    ratn: not reported in source

    Carrageenan-induced hindpaw inflammation
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    1000 microg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    In addition, rats with carrageenan-induced inflammation given oxytocin (1000 microg/kg s.c.) responded differently to nociceptive mechanical stimulation (P < 0.05)
    1 context sentence
    Summary · context
    The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with carrageenan-induced inflammation, oxytocin at 1000 microg/kg reduced paw myeloperoxidase, a marker of neutrophil recruitment.

    In plain wordsIn rats with paw inflammation, oxytocin at 1000 micrograms per kilogram lowered a marker of white blood cell arrival in the paw.

    Peptide
    Oxytocin
    Outcome
    DecreasePaw myeloperoxidase
    Study

    ratn: not reported in source

    Carrageenan-induced hindpaw inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    1000 microg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    had a reduced amount of myeloperoxidase (marker for neutrophil recruitment) in the paw (P < 0.01).
    1 context sentence
    Summary · context
    The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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