In rats, exposure to oil after MTII infusion left responding to the tone high, unlike food satiation, which reduced it.
In plain wordsIn rats, MTII did not lower tone-driven responding the way food satiation did, so it acts differently from fullness.
- Peptide
- Melanotan II
- Outcome
- IncreaseResponding to the tone in the extinction test after exposure with MTII
- Study
ratn: not reported in source
rats trained that a tone predicted peanut oil- Comparator
- Sated exposure
- Outcome group
- Appetite and food intake · Nervous system and cognition
- Studied dose
- Dose not stated · intra-third-cerebroventricular infusionAs given in this study (rat).
Source sentences
Unlike satiation, rats that received exposure after MTII exhibited continued high levels of responding to the tone.
1 context sentence(design, population, supporting numbers)
They then received exposure to oil under food deprivation, satiation, intra-third-cerebroventricular (i3vt) infusion of MTII (a potent MC agonist) or SHU-9119 (a potent MC antagonist).