Differential effects of retinoids on proliferation of bovine mammary epithelial cells in collagen gel culture.

Purup S, Jensen SK, Sejrsen K

The Journal of dairy research1 May 2001Cited by 15 (Europe PMC)

PMID11504380DOI10.1017/s0022029901004782PepBankPUB-11504380

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

01LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In bovine mammary cells, retinol inhibited proliferation stimulated by des(1‑3)IGF-I and other growth factors.
In plain wordsIn cells, retinol reduced growth stimulated by des(1‑3)IGF-I and other factors compared with stimulation alone.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRetinol inhibition of proliferation
Study
bovinen: not reported in source
Mammary epithelial cells in collagen gel
Comparator
Growth-factor stimulation without retinoid
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Retinol and retinoic acid also inhibited proliferation of cells growth-stimulated by insulin and other growth factors from the IGF growth factor family (des(1-3)IGF-I and IGF-II), as well as growth factors from the epidermal growth factor family (EGF and TGF-alpha), with retinoic acid being more effective than retinol.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of increasing concentrations of retinol, retinal and retinoic acid on proliferation of bovine mammary epithelial cells were investigated in collagen gel cultures.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1150438001
02LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In bovine mammary cells, retinoic acid inhibited des(1‑3)IGF-I-stimulated proliferation more effectively than retinol.
In plain wordsIn cells, retinoic acid reduced des(1‑3)IGF-I-stimulated growth more than retinol.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRetinoic acid inhibition of proliferation
Study
bovinen: not reported in source
Mammary epithelial cells in collagen gel
Comparator
Retinol
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Retinol and retinoic acid also inhibited proliferation of cells growth-stimulated by insulin and other growth factors from the IGF growth factor family (des(1-3)IGF-I and IGF-II), as well as growth factors from the epidermal growth factor family (EGF and TGF-alpha), with retinoic acid being more effective than retinol.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of increasing concentrations of retinol, retinal and retinoic acid on proliferation of bovine mammary epithelial cells were investigated in collagen gel cultures.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1150438002
03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In bovine mammary cells, retinol at 100 ng/ml inhibited IGF-family-stimulated proliferation by 24-38%.
In plain wordsIn cells, retinol inhibited growth stimulated by pooled IGF-family factors, including des(1‑3)IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRetinol inhibition of IGF-family-stimulated proliferation
Study
bovinen: not reported in source
Mammary epithelial cells in collagen gel
Comparator
Growth-factor stimulation without retinoid
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Measurements
Proliferation inhibition
24 to 38%
retinol 100 ng/ml; IGF-family factors
Source sentences
Summary
At a concentration of 100 ng/ml retinol and retinoic acid inhibited respectively 24-38 and 44-52% of mammary cell proliferation stimulated by growth factors of the IGF family, and at 10,000 ng/ml, 61-71% of cell proliferation was inhibited.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of increasing concentrations of retinol, retinal and retinoic acid on proliferation of bovine mammary epithelial cells were investigated in collagen gel cultures.
Summary · context
Retinol and retinoic acid also inhibited proliferation of cells growth-stimulated by insulin and other growth factors from the IGF growth factor family (des(1-3)IGF-I and IGF-II), as well as growth factors from the epidermal growth factor family (EGF and TGF-alpha), with retinoic acid being more effective than retinol.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1150438003
04LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In bovine mammary cells, retinoic acid at 100 ng/ml inhibited IGF-family-stimulated proliferation by 44-52%.
In plain wordsIn cells, retinoic acid inhibited growth stimulated by pooled IGF-family factors, including des(1‑3)IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRetinoic acid inhibition of IGF-family-stimulated proliferation
Study
bovinen: not reported in source
Mammary epithelial cells in collagen gel
Comparator
Growth-factor stimulation without retinoid
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Measurements
Proliferation inhibition
44 to 52%
retinoic acid 100 ng/ml; IGF-family factors
Source sentences
Summary
At a concentration of 100 ng/ml retinol and retinoic acid inhibited respectively 24-38 and 44-52% of mammary cell proliferation stimulated by growth factors of the IGF family, and at 10,000 ng/ml, 61-71% of cell proliferation was inhibited.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of increasing concentrations of retinol, retinal and retinoic acid on proliferation of bovine mammary epithelial cells were investigated in collagen gel cultures.
Summary · context
Retinol and retinoic acid also inhibited proliferation of cells growth-stimulated by insulin and other growth factors from the IGF growth factor family (des(1-3)IGF-I and IGF-II), as well as growth factors from the epidermal growth factor family (EGF and TGF-alpha), with retinoic acid being more effective than retinol.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1150438004
05LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In bovine mammary cells, retinoids at 10,000 ng/ml inhibited IGF-family-stimulated proliferation by 61-71%.
In plain wordsIn cells, high-concentration retinoids inhibited growth stimulated by pooled IGF-family factors, including des(1‑3)IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseHigh-concentration retinoid inhibition of IGF-family-stimulated proliferation
Study
bovinen: not reported in source
Mammary epithelial cells in collagen gel
Comparator
Growth-factor stimulation without retinoid
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Measurements
Proliferation inhibition
61 to 71%
retinoids 10,000 ng/ml; IGF-family factors
Source sentences
Summary
At a concentration of 100 ng/ml retinol and retinoic acid inhibited respectively 24-38 and 44-52% of mammary cell proliferation stimulated by growth factors of the IGF family, and at 10,000 ng/ml, 61-71% of cell proliferation was inhibited.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of increasing concentrations of retinol, retinal and retinoic acid on proliferation of bovine mammary epithelial cells were investigated in collagen gel cultures.
Summary · context
Retinol and retinoic acid also inhibited proliferation of cells growth-stimulated by insulin and other growth factors from the IGF growth factor family (des(1-3)IGF-I and IGF-II), as well as growth factors from the epidermal growth factor family (EGF and TGF-alpha), with retinoic acid being more effective than retinol.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-1150438005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:52 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.