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Study · In vitro (cells) · chick · 2001

6 results

Antiapoptotic effects of the peptidergic drug cerebrolysin on primary cultures of embryonic chick cortical neurons.

Hartbauer M, Hutter-Paier B, Skofitsch G, Windisch M

Journal of neural transmission (Vienna, Austria : 1996)1 Jan 2001Cited by 45 (Europe PMC)

PMID11475013 (opens in a new tab)DOI10.1007/s007020170067 (opens in a new tab)PepBankPUB-11475013
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In chick neuronal cultures, Cerebrolysin and AA-mix produced similar increases in viability after 4 DIV.

    In plain wordsIn cells from chicks, Cerebrolysin and AA-mix increased survival similarly after 4 DIV.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedViability after 4 DIV
    Study

    chickn: not reported in source

    Embryonic cortical neuron cultures under low serum stress
    Comparator
    AA-mix
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin, the AA-mix and 10% foetal calf serum (FCS) caused a similar increase in viability after 4 DIV, whereas the effects of the growth factors BDNF and FGF-2 were less pronounced.
    2 context sentences
    Summary · context
    In this study we used a low serum (2% serum supplement) cell stress in-vitro model to assess drug effectiveness on neuronal viability and programmed cell death (PCD).
    Summary · context
    To differentiate between possible effects of the free amino acids and the peptide fraction of Cerebrolysin an artificial amino acid mixture (AA-mix) was used as a control.
  2. 02LabIn vitro (cells)Efficacy outcome

    In chick neuronal cultures, Cerebrolysin increased viability more than BDNF after 4 DIV.

    In plain wordsIn cells from chicks, Cerebrolysin increased survival more than BDNF after 4 DIV.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseViability after 4 DIV versus BDNF
    Study

    chickn: not reported in source

    Embryonic cortical neuron cultures under low serum stress
    Comparator
    BDNF
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin, the AA-mix and 10% foetal calf serum (FCS) caused a similar increase in viability after 4 DIV, whereas the effects of the growth factors BDNF and FGF-2 were less pronounced.
    2 context sentences
    Summary · context
    In this study we used a low serum (2% serum supplement) cell stress in-vitro model to assess drug effectiveness on neuronal viability and programmed cell death (PCD).
    Summary · context
    To differentiate between possible effects of the free amino acids and the peptide fraction of Cerebrolysin an artificial amino acid mixture (AA-mix) was used as a control.
  3. 03LabIn vitro (cells)Efficacy outcome

    In chick neuronal cultures, Cerebrolysin increased viability more than FGF-2 after 4 DIV.

    In plain wordsIn cells from chicks, Cerebrolysin increased survival more than FGF-2 after 4 DIV.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseViability after 4 DIV versus FGF-2
    Study

    chickn: not reported in source

    Embryonic cortical neuron cultures under low serum stress
    Comparator
    FGF-2
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin, the AA-mix and 10% foetal calf serum (FCS) caused a similar increase in viability after 4 DIV, whereas the effects of the growth factors BDNF and FGF-2 were less pronounced.
    2 context sentences
    Summary · context
    In this study we used a low serum (2% serum supplement) cell stress in-vitro model to assess drug effectiveness on neuronal viability and programmed cell death (PCD).
    Summary · context
    To differentiate between possible effects of the free amino acids and the peptide fraction of Cerebrolysin an artificial amino acid mixture (AA-mix) was used as a control.
  4. 04LabIn vitro (cells)Efficacy outcome

    In chick neuronal cultures, Cerebrolysin improved viability after 8 DIV, whereas AA-mix did not.

    In plain wordsIn cells from chicks, Cerebrolysin improved survival after 8 DIV, whereas AA-mix did not.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseViability after 8 DIV
    Study

    chickn: not reported in source

    Embryonic cortical neuron cultures under low serum stress
    Comparator
    AA-mix
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After 8 DIV Cerebrolysin, but not the AA-mix, was able to ameliorate neuronal viability, which could reflect a neuro-protective effect or an increased activity of the mitochondrial dehydrogenase measured in a MTT-reduction assay.
    2 context sentences
    Summary · context
    In this study we used a low serum (2% serum supplement) cell stress in-vitro model to assess drug effectiveness on neuronal viability and programmed cell death (PCD).
    Summary · context
    To differentiate between possible effects of the free amino acids and the peptide fraction of Cerebrolysin an artificial amino acid mixture (AA-mix) was used as a control.
  5. 05LabIn vitro (cells)Efficacy outcome

    In chick neuronal cultures, Cerebrolysin reduced apoptotic chromatin changes (p < 0.01), whereas AA-mix did not.

    In plain wordsIn cells from chicks, Cerebrolysin reduced programmed cell death markers, whereas AA-mix did not.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseApoptotic chromatin changes
    Study

    chickn: not reported in source

    Embryonic cortical neuron cultures under low serum stress
    Comparator
    AA-mix
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The percentage of cells showing apoptotic chromatin changes was significantly reduced (p < 0.01) in cultures treated with Cerebrolysin, whereas the AA-mix failed to decrease the percentage of cells showing apoptotic chromatin changes.
    2 context sentences
    Summary · context
    In this study we used a low serum (2% serum supplement) cell stress in-vitro model to assess drug effectiveness on neuronal viability and programmed cell death (PCD).
    Summary · context
    To differentiate between possible effects of the free amino acids and the peptide fraction of Cerebrolysin an artificial amino acid mixture (AA-mix) was used as a control.
  6. 06LabIn vitro (cells)Efficacy outcome

    In chick neuronal cultures, Cerebrolysin and 10% foetal calf serum produced similar increases in viability after 4 DIV.

    In plain wordsIn cells from chicks, Cerebrolysin and 10% foetal calf serum increased survival similarly after 4 DIV.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedViability after 4 DIV versus 10% FCS
    Study

    chickn: not reported in source

    Embryonic cortical neuron cultures under low serum stress
    Comparator
    10% foetal calf serum
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin, the AA-mix and 10% foetal calf serum (FCS) caused a similar increase in viability after 4 DIV, whereas the effects of the growth factors BDNF and FGF-2 were less pronounced.
    2 context sentences
    Summary · context
    In this study we used a low serum (2% serum supplement) cell stress in-vitro model to assess drug effectiveness on neuronal viability and programmed cell death (PCD).
    Summary · context
    To differentiate between possible effects of the free amino acids and the peptide fraction of Cerebrolysin an artificial amino acid mixture (AA-mix) was used as a control.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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