In pigs, intrajejunal octreotide without polymer had bioavailability of 1.7 +/- 1.1% (mean +/- SE).
In plain wordsIn pigs, octreotide given into the jejunum without polymer had bioavailability of 1.7 +/- 1.1%.
- Peptide
- Octreotide
- Outcome
- Not applicableBioavailability at 10 mg
- Study
pign = 6
Juvenile female pigs with jejunal stoma and fistula- Outcome group
- Pharmacokinetics · Pharmacology
- Studied dose
- 10 mg · intrajejunalAs given in this study (pig).
Measurements
- Bioavailability
- 1.7%
- 10 mg octreotide without polymer
- Standard error
- 1.1%
- 10 mg octreotide without polymer
Source sentences
Intrajejunal administration of 10 mg octreotide without any polymer (control solution) resulted in F values of 1.7 +/- 1.1% (mean +/- SE).
3 context sentences(design, population, supporting numbers)
Six female pigs (body weight, 25 kg) were operated to induce a stoma at the beginning of their jejunum and to insert an in-dwelling fistula for intrajejunal (IJ) administration of the formulations.
One week after surgery the pigs received IJ octreotide solution administrations with or without TMC at pH 7.4 or chitosan HCl at pH 5.5.
For determining bioavailability (F) values, the pigs also received an octreotide solution intravenously (IV).