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Study · Measured the body's own peptide · 2001

4 results

Distribution of delta sleep-inducing peptide in the newborn and infant human hypothalamus: an immunohistochemical study.

Najimi M, Bennis M, Moyse E, Chigr F

Biological research1 Jan 2001Cited by 2 (Europe PMC)

PMID11471521 (opens in a new tab)DOI10.4067/s0716-97602001000100013 (opens in a new tab)PepBankPUB-11471521
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In the normal human infant hypothalamus, few DSIP-immunoreactive perikarya were present, mostly scattered through the preoptic region and the infundibular nucleus.

    In plain wordsIn infant brain tissue, the body's own DSIP was found in few nerve cell bodies, mostly in two hypothalamic regions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP-immunoreactive cell bodies in hypothalamus
    Study

    n: not reported in source

    normal human hypothalamus, first postnatal year
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    Immunolabeled perikarya were relatively few and were mostly scattered through the anterior (preoptic) and mediobasal regions (infundibular nucleus) of the hypothalamus.
    1 context sentence
    Summary · context
    The distribution of delta sleep-inducing peptide immunoreactive cell bodies, fibers, and terminal-like structures was investigated in the normal human hypothalamus during the first postnatal year, using immunohistofluorescence and peroxidase anti-peroxidase techniques.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In the normal human infant hypothalamus, DSIP-immunoreactive fibers occurred along the whole hypothalamus, with high densities in the preoptic region, the organum vasculosum of lamina terminalis, the infundibular nucleus and the median eminence.

    In plain wordsIn infant brain tissue, the body's own DSIP was seen in nerve fibres throughout the hypothalamus, most densely in four regions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP-immunoreactive fibers, high-density regions
    Study

    n: not reported in source

    normal human hypothalamus, first postnatal year
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    DSIP-immunoreactive fibers and terminal-like fibers were observed throughout the entire rostrocaudal extent of the hypothalamus. They exhibit high densities in the preoptic region, the organum vasculosum of lamina terminalis, infundibular nucleus and median eminence.
    1 context sentence
    Summary · context
    The distribution of delta sleep-inducing peptide immunoreactive cell bodies, fibers, and terminal-like structures was investigated in the normal human hypothalamus during the first postnatal year, using immunohistofluorescence and peroxidase anti-peroxidase techniques.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In the normal human infant hypothalamus, DSIP-immunoreactive fibers had moderate to low density in the other anterior and mediobasal hypothalamic nuclei.

    In plain wordsIn infant brain tissue, the body's own DSIP appeared at moderate to low levels in other hypothalamic areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableDSIP-immunoreactive fibers, other hypothalamic nuclei
    Study

    n: not reported in source

    normal human hypothalamus, first postnatal year
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    Moderate to low densities of DSIP-immunoreactive fibers were observed in the other hypothalamic structures, located in the anterior and mediobasal regions of hypothalamus, such as periventricular, paraventricular, suprachiasmatic, ventromedial, dorsomedial and parafornical nuclei.
    1 context sentence
    Summary · context
    The distribution of delta sleep-inducing peptide immunoreactive cell bodies, fibers, and terminal-like structures was investigated in the normal human hypothalamus during the first postnatal year, using immunohistofluorescence and peroxidase anti-peroxidase techniques.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In the human hypothalamus during the first postnatal year, qualitative age-related changes in DSIP immunoreactivity density occurred in the anterior region and the median eminence; the direction is not stated.

    In plain wordsIn infant brain tissue, natural DSIP levels changed with age in some hypothalamic areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedAge-related change in DSIP immunoreactivity density
    Study

    n: not reported in source

    normal human hypothalamus, first postnatal year
    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    We have found qualitative age-related changes in the density of DSIP immunoreactivity in several hypothalamic structures such as the anterior region and the median eminence.
    1 context sentence
    Summary · context
    The distribution of delta sleep-inducing peptide immunoreactive cell bodies, fibers, and terminal-like structures was investigated in the normal human hypothalamus during the first postnatal year, using immunohistofluorescence and peroxidase anti-peroxidase techniques.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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