Skip to content

Study · In vitro (cells) · 2001

4 results

Amplification of blood-brain barrier GLUT1 glucose transporter gene expression by brain-derived peptides.

Boado RJ

Neuroscience research1 Aug 2001Cited by 10 (Europe PMC)

PMID11463479 (opens in a new tab)DOI10.1016/s0168-0102(01)00246-2 (opens in a new tab)PepBankPUB-11463479
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin dose-dependently increased reporter expression with GLUT1 translation and mRNA stabilization elements.

    In plain wordsIn cells, Cerebrolysin increased reporter expression when GLUT1 regulatory elements were present.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGLUT1 reporter expression
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cl markedly increased the expression of reporter genes containing GLUT1 translational control elements and cis-acting elements involved in the stabilization of the GLUT1 mRNA transcript in a dose dependent manner.
    1 context sentence
    Summary · context
    In order to gain more insights into the mechanism of BBB-GLUT1 gene regulation, the present investigation studied the effect of Cl on the expression of both the GLUT1 protein and GLUT1 reporter genes in brain endothelial cultured cells (ECL).
  2. 02LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin produced only marginal effects on a reporter lacking GLUT1 regulatory elements.

    In plain wordsIn cells, Cerebrolysin had only marginal effects on a reporter without GLUT1 regulatory elements.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedControl reporter expression
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cl produced only marginal effects on the reporter gene control lacking the GLUT1 regulatory elements.
    1 context sentence
    Summary · context
    In order to gain more insights into the mechanism of BBB-GLUT1 gene regulation, the present investigation studied the effect of Cl on the expression of both the GLUT1 protein and GLUT1 reporter genes in brain endothelial cultured cells (ECL).
  3. 03LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin markedly increased glucose uptake.

    In plain wordsIn cells, Cerebrolysin increased glucose uptake.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGlucose uptake
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In parallel experiments, Cl markedly increased the uptake of 3H-2-deoxy-D-glucose and the levels of the GLUT1 protein measured by ELISA.
    1 context sentence
    Summary · context
    In order to gain more insights into the mechanism of BBB-GLUT1 gene regulation, the present investigation studied the effect of Cl on the expression of both the GLUT1 protein and GLUT1 reporter genes in brain endothelial cultured cells (ECL).
  4. 04LabIn vitro (cells)Mechanism

    In brain endothelial cells, Cerebrolysin markedly increased GLUT1 protein levels measured by ELISA.

    In plain wordsIn cells, Cerebrolysin increased GLUT1 protein levels.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGLUT1 protein levels
    Study

    n: not reported in source

    Brain endothelial cultured cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In parallel experiments, Cl markedly increased the uptake of 3H-2-deoxy-D-glucose and the levels of the GLUT1 protein measured by ELISA.
    1 context sentence
    Summary · context
    In order to gain more insights into the mechanism of BBB-GLUT1 gene regulation, the present investigation studied the effect of Cl on the expression of both the GLUT1 protein and GLUT1 reporter genes in brain endothelial cultured cells (ECL).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.