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Study · In vitro (cells) · chicken · 2001

3 results

Effects of Cerebrolysin on the outgrowth and protection of processes of cultured brain neurons.

Hartbauer M, Hutter-Paie B, Windisch M

Journal of neural transmission (Vienna, Austria : 1996)1 Jan 2001Cited by 33 (Europe PMC)

PMID11459078 (opens in a new tab)DOI10.1007/s007020170058 (opens in a new tab)PepBankPUB-11459078
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In embryonic chicken neurons, Cerebrolysin promoted process outgrowth after 4 DIV.

    In plain wordsIn cells from chickens, Cerebrolysin promoted nerve process growth after 4 DIV.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseProcess outgrowth after 4 DIV
    Study

    chickenn: not reported in source

    Embryonic neuronal cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Results demonstrate a process outgrowth promoting effect of the AA-mix and Cere after 4 DIV.
    2 context sentences
    Summary · context
    This was accomplished by quantification of the neurite lengths of embryonic chicken telencephalon neurons after 4 and 8 days.
    Summary · context
    To distinguish between effects caused by the peptide fraction and the effects related to free amino acids, we used an artificial amino acid solution (AA-mix).
  2. 02LabIn vitro (cells)Efficacy outcome

    In chicken neuronal cultures, Cerebrolysin preserved differentiated networks after 8 days, whereas AA-mix cultures degenerated.

    In plain wordsIn cells from chickens, Cerebrolysin preserved nerve networks after 8 days compared with degeneration under AA-mix.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNetwork degeneration after 8 days
    Study

    chickenn: not reported in source

    Embryonic neuronal cultures
    Comparator
    AA-mix
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After 8 days neuronal network degeneration occurred in the AA-mix treated cultures, whereas Cere treated cultures still presented a well differentiated neuronal network.
    2 context sentences
    Summary · context
    This was accomplished by quantification of the neurite lengths of embryonic chicken telencephalon neurons after 4 and 8 days.
    Summary · context
    To distinguish between effects caused by the peptide fraction and the effects related to free amino acids, we used an artificial amino acid solution (AA-mix).
  3. 03LabIn vitro (cells)Efficacy outcome

    In chicken neuronal cultures, Cerebrolysin significantly decreased random growth cone movement velocities.

    In plain wordsIn cells from chickens, Cerebrolysin reduced the speed of random growth cone movements.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseRandom growth cone movement velocity
    Study

    chickenn: not reported in source

    Embryonic neuronal cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Time-lapse studies of Cere treated cultures revealed a significant decrease of the velocities characterising random growth cone movements, which is thought to be responsible for an increase in the length of axon-like processes after 4 DIV.
    2 context sentences
    Summary · context
    This was accomplished by quantification of the neurite lengths of embryonic chicken telencephalon neurons after 4 and 8 days.
    Summary · context
    To distinguish between effects caused by the peptide fraction and the effects related to free amino acids, we used an artificial amino acid solution (AA-mix).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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