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Study · In vitro (cells) · rat · 2001

2 results

Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog.

Shadrina MI, Dolotov OV, Grivennikov IA, Slominsky PA, Andreeva LA, Inozemtseva LS, Limborska SA, Myasoedov NF

Neuroscience letters1 Aug 2001Cited by 33 (Europe PMC)

PMID11457573 (opens in a new tab)DOI10.1016/s0304-3940(01)01994-2 (opens in a new tab)PepBankPUB-11457573
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat glial cell cultures, Semax increased BDNF mRNA level eight-fold compared with control after 30 min.

    In plain wordsIn rat brain cells in culture, Semax raised BDNF messenger RNA eight-fold compared with control after 30 min.

    Peptide
    Semax
    Outcome
    IncreaseBDNF mRNA level at 30 min
    Study

    ratn: not reported in source

    Primary glial cell cultures from rat basal forebrain
    Comparator
    Control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 30 minAs given in this study (rat).

    Source sentences

    Summary
    BDNF mRNA level was increased eight-fold in comparison with control
    2 context sentences
    Summary · context
    The greatest increase in expression was found after 30 min of 'Semax' administration.
    Summary · context
    To test this hypothesis we analyzed NGF and BDNF gene expression in glial cells obtained from the basal forebrain of newborn rats, following in vitro treatment with 'Semax'.
  2. 02LabIn vitro (cells)Mechanism

    In rat glial cell cultures, Semax increased NGF mRNA level five-fold compared with control after 30 min.

    In plain wordsIn rat brain cells in culture, Semax raised NGF messenger RNA five-fold compared with control after 30 min.

    Peptide
    Semax
    Outcome
    IncreaseNGF mRNA level at 30 min
    Study

    ratn: not reported in source

    Primary glial cell cultures from rat basal forebrain
    Comparator
    Control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 30 minAs given in this study (rat).

    Source sentences

    Summary
    At this time, BDNF mRNA level was increased eight-fold in comparison with control, and NGF mRNA level was increased five-fold.
    2 context sentences
    Summary · context
    The greatest increase in expression was found after 30 min of 'Semax' administration.
    Summary · context
    To test this hypothesis we analyzed NGF and BDNF gene expression in glial cells obtained from the basal forebrain of newborn rats, following in vitro treatment with 'Semax'.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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