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Study · Animal study (in vivo) · rat · 2001

4 results

Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats.

Hwa JJ, Ghibaudi L, Gao J, Parker EM

American journal of physiology. Regulatory, integrative and comparative physiology1 Aug 2001Cited by 70 (Europe PMC)

PMID11448846 (opens in a new tab)DOI10.1152/ajpregu.2001.281.2.r444 (opens in a new tab)PepBankPUB-11448846
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In lean and obese Zucker rats, the melanocortin agonist MTII reduced food intake.

    In plain wordsIn rats, MTII reduced food intake in both lean and obese Zucker rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake
    Study

    ratn: not reported in source

    lean and obese Zucker rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, the melanocortin receptor agonist MTII reduced food intake in both lean and obese rats but was more potent in the obese Zucker rats.
    1 context sentence
    Summary · context
    The purpose of this study was to use a melanocortin receptor agonist and antagonist to evaluate the involvement of melanocortins in feeding, energy metabolism, and body weight regulation in lean and obese Zucker rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    MTII was more potent at reducing food intake in obese Zucker rats than in lean Zucker rats.

    In plain wordsIn rats, MTII reduced food intake more potently in obese Zucker rats than in lean ones.

    Peptide
    Melanotan II
    Outcome
    DecreasePotency on food intake, obese versus lean
    Study

    ratn: not reported in source

    lean and obese Zucker rats
    Comparator
    Lean Zucker rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, the melanocortin receptor agonist MTII reduced food intake in both lean and obese rats but was more potent in the obese Zucker rats.
    1 context sentence
    Summary · context
    The purpose of this study was to use a melanocortin receptor agonist and antagonist to evaluate the involvement of melanocortins in feeding, energy metabolism, and body weight regulation in lean and obese Zucker rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker rats, MTII infusion elevated oxygen consumption during the light cycle.

    In plain wordsIn rats, MTII infusion raised oxygen consumption, a sign of higher energy use.

    Peptide
    Melanotan II
    Outcome
    IncreaseOxygen consumption
    Study

    ratn: not reported in source

    lean and obese Zucker rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTII infusion elevated oxygen consumption and decreased respiratory quotient dose dependently during the light cycle
    1 context sentence
    Summary · context
    The purpose of this study was to use a melanocortin receptor agonist and antagonist to evaluate the involvement of melanocortins in feeding, energy metabolism, and body weight regulation in lean and obese Zucker rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Zucker rats, MTII infusion decreased the respiratory quotient dose dependently during the light cycle.

    In plain wordsIn rats, MTII infusion lowered the respiratory quotient, which fits more fat burning, with larger effects at higher doses.

    Peptide
    Melanotan II
    Outcome
    DecreaseRespiratory quotient
    Study

    ratn: not reported in source

    lean and obese Zucker rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTII infusion elevated oxygen consumption and decreased respiratory quotient dose dependently during the light cycle
    1 context sentence
    Summary · context
    The purpose of this study was to use a melanocortin receptor agonist and antagonist to evaluate the involvement of melanocortins in feeding, energy metabolism, and body weight regulation in lean and obese Zucker rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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