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Study · Non-randomized trial · n = 19 · 2001

7 results

Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor.

Gondo RG, Aguiar-Oliveira MH, Hayashida CY, Toledo SP, Abelin N, Levine MA, Bowers CY, Souza AH, Pereira RM, Santos NL, Salvatori R

The Journal of clinical endocrinology and metabolism1 Jul 2001Cited by 39 (Europe PMC)

PMID11443201 (opens in a new tab)DOI10.1210/jcem.86.7.7694 (opens in a new tab)PepBankPUB-11443201
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    The GH response to GHRP‑2 was significantly smaller in individuals with GH deficiency from a GHRH receptor mutation than in controls.

    In plain wordsPeople with GH deficiency from a GHRH receptor mutation had a smaller GH response to GHRP‑2 than healthy controls.

    Peptide
    GHRP-2
    Outcome
    DecreaseGH response to GHRP-2 in GH deficiency versus controls
    Study

    n = 19

    Comparator
    Normal controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After GHRP-2 administration there was a 4.5-fold increase in serum GH relative to baseline values in the GHD group (0.49 +/- 0.41 vs. 0.11 +/- 0.11 microg/L; P = 0.002), which was significantly less than the 79-fold increase in the control group (46.8 +/- 17.6 vs. 0.59 +/- 0.76 microg/L; P = 0.008).
    1 context sentence
    Summary · context
    In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls.
  2. 02HumanNon-randomized trialEfficacy outcome

    Basal and post-GHRP‑2 serum ACTH levels were similar in the GH-deficient and control groups.

    In plain wordsACTH levels, before and after GHRP‑2, were similar in people with GH deficiency and in healthy controls.

    Peptide
    GHRP-2
    Outcome
    No significant changeACTH levels after GHRP-2
    Study

    n = 19

    Comparator
    Normal controls
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Basal and post-GHRP-2 serum levels of ACTH, cortisol, and PRL were similar in both groups.
    1 context sentence
    Summary · context
    In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls.
  3. 03HumanNon-randomized trialEfficacy outcome

    Basal and post-GHRP‑2 serum cortisol levels were similar in the GH-deficient and control groups.

    In plain wordsCortisol levels, before and after GHRP‑2, were similar in people with GH deficiency and in healthy controls.

    Peptide
    GHRP-2
    Outcome
    No significant changeCortisol levels after GHRP-2
    Study

    n = 19

    Comparator
    Normal controls
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Basal and post-GHRP-2 serum levels of ACTH, cortisol, and PRL were similar in both groups.
    1 context sentence
    Summary · context
    In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls.
  4. 04HumanNon-randomized trialEfficacy outcome

    Basal and post-GHRP‑2 serum PRL levels were similar in the GH-deficient and control groups.

    In plain wordsProlactin levels, before and after GHRP‑2, were similar in people with GH deficiency and in healthy controls.

    Peptide
    GHRP-2
    Outcome
    No significant changeProlactin levels after GHRP-2
    Study

    n = 19

    Comparator
    Normal controls
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Basal and post-GHRP-2 serum levels of ACTH, cortisol, and PRL were similar in both groups.
    1 context sentence
    Summary · context
    In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls.
  5. 05HumanNon-randomized trialEfficacy outcome

    Serum TSH levels did not change after GHRP‑2 administration in either the GH-deficient group or the control group.

    In plain wordsTSH levels did not change after GHRP‑2 in people with GH deficiency or in healthy controls.

    Peptide
    GHRP-2
    Outcome
    No significant changeTSH levels after GHRP-2
    Study

    n = 19

    Comparator
    Baseline
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TSH levels in both groups did not change after GHRP-2 administration.
    1 context sentence
    Summary · context
    In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls.
  6. 06HumanNon-randomized trialEfficacy outcome

    In individuals with isolated GH deficiency due to a homozygous GHRH receptor mutation, GHRP‑2 increased serum GH 4.5-fold relative to baseline.

    In plain wordsIn people with GH deficiency from a GHRH receptor mutation, GHRP‑2 raised GH levels 4.5-fold above baseline.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum GH after GHRP-2 in isolated GH deficiency
    Study

    n = 11

    Comparator
    Baseline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GH fold increase
    4.5 fold
    GHD group

    Source sentences

    Summary
    After GHRP-2 administration there was a 4.5-fold increase in serum GH relative to baseline values in the GHD group (0.49 +/- 0.41 vs. 0.11 +/- 0.11 microg/L; P = 0.002)
    1 context sentence
    Summary · context
    In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls.
  7. 07HumanNon-randomized trialEfficacy outcome

    In normal unrelated controls, GHRP‑2 increased serum GH 79-fold relative to baseline.

    In plain wordsIn healthy controls, GHRP‑2 raised GH levels 79-fold above baseline.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum GH after GHRP-2 in normal controls
    Study

    n = 8

    Comparator
    Baseline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    GH fold increase
    79 fold
    control group

    Source sentences

    Summary
    which was significantly less than the 79-fold increase in the control group (46.8 +/- 17.6 vs. 0.59 +/- 0.76 microg/L; P = 0.008).
    1 context sentence
    Summary · context
    In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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