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Study · In vitro (cells) · rat · 2001

6 results

Vasoactive intestinal peptide and related molecules induce nitrite accumulation in the extracellular milieu of rat cerebral cortical cultures.

Ashur-Fabian O, Giladi E, Furman S, Steingart RA, Wollman Y, Fridkin M, Brenneman DE, Gozes I

Neuroscience letters1 Jul 2001Cited by 29 (Europe PMC)

PMID11438390 (opens in a new tab)DOI10.1016/s0304-3940(01)01954-1 (opens in a new tab)PepBankPUB-11438390
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat cerebral cortical cultures, NAP increased intracellular cGMP by 2.5-4-fold.

    In plain wordsIn lab tests, NAP increased cGMP inside rat cortical cells by 2.5-4-fold.

    Peptide
    Davunetide
    Outcome
    IncreaseIntracellular cGMP
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-16)-10(-7) MAs given in this study (rat).

    Measurements

    Intracellular cGMP increase
    2.5 to 4 fold
    NAP

    Source sentences

    Summary
    In rat cerebral cortical cultures, 10(-16)-10(-7) M NAP increased intracellular cyclic guanosine monophosphate (cGMP) (2.5-4-fold) and 10(-10) M NAP increased extracellular nitric oxide (NO) by 60%.
  2. 02LabIn vitro (cells)Mechanism

    In rat cerebral cortical cultures, NAP increased extracellular nitric oxide by 60%.

    In plain wordsIn lab tests, NAP increased nitric oxide outside rat cortical cells by 60%.

    Peptide
    Davunetide
    Outcome
    IncreaseExtracellular nitric oxide
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-10) MAs given in this study (rat).

    Measurements

    Extracellular nitric oxide increase
    60%
    NAP

    Source sentences

    Summary
    In rat cerebral cortical cultures, 10(-16)-10(-7) M NAP increased intracellular cyclic guanosine monophosphate (cGMP) (2.5-4-fold) and 10(-10) M NAP increased extracellular nitric oxide (NO) by 60%.
  3. 03LabIn vitro (cells)Mechanism

    In rat cerebral cortical cultures, VIP increased extracellular nitric oxide within the reported 45-55% range for VIP and SNV.

    In plain wordsIn lab tests, VIP increased nitric oxide outside rat cortical cells within the reported 45-55% range.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseExtracellular nitric oxide
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    micromolar concentrationsAs given in this study (rat).

    Measurements

    Extracellular nitric oxide increase
    45 to 55%
    Reported range for VIP and SNV

    Source sentences

    Summary
    In the same culture system, VIP and SNV (at micromolar concentrations) increased extracellular NO by 45-55%.
    1 context sentence
    Summary · context
    In rat cerebral cortical cultures, 10(-16)-10(-7) M NAP increased intracellular cyclic guanosine monophosphate (cGMP) (2.5-4-fold) and 10(-10) M NAP increased extracellular nitric oxide (NO) by 60%.
  4. 04LabIn vitro (cells)Mechanism

    In rat cerebral cortical cultures, the NAP dose required for cGMP increases correlated with its neuroprotective dose.

    In plain wordsIn lab tests, NAP doses that increased cGMP correlated with doses that protected rat cortical cells.

    Peptide
    Davunetide
    Outcome
    Not applicablecGMP and neuroprotection dose relationship
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The NAP dose required for cGMP increases correlated with the dose providing neuroprotection.
    1 context sentence
    Summary · context
    In rat cerebral cortical cultures, 10(-16)-10(-7) M NAP increased intracellular cyclic guanosine monophosphate (cGMP) (2.5-4-fold) and 10(-10) M NAP increased extracellular nitric oxide (NO) by 60%.
  5. 05LabIn vitro (cells)Mechanism

    In rat cerebral cortical cultures, NAP concentrations affecting nitric oxide production did not match neuroprotective doses.

    In plain wordsIn lab tests, NAP doses affecting nitric oxide did not match doses that protected rat cortical cells.

    Peptide
    Davunetide
    Outcome
    Not applicableNitric oxide and neuroprotection dose mismatch
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the concentrations of NAP, SNV and VIP affecting NO production did not match the neuro-protective doses.
    1 context sentence
    Summary · context
    In rat cerebral cortical cultures, 10(-16)-10(-7) M NAP increased intracellular cyclic guanosine monophosphate (cGMP) (2.5-4-fold) and 10(-10) M NAP increased extracellular nitric oxide (NO) by 60%.
  6. 06LabIn vitro (cells)Mechanism

    In rat cerebral cortical cultures, VIP concentrations affecting nitric oxide production did not match neuroprotective doses.

    In plain wordsIn lab tests, VIP doses affecting nitric oxide did not match doses that protected rat cortical cells.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableNitric oxide and neuroprotection dose mismatch
    Study

    ratn: not reported in source

    Cerebral cortical cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the concentrations of NAP, SNV and VIP affecting NO production did not match the neuro-protective doses.
    1 context sentence
    Summary · context
    In the same culture system, VIP and SNV (at micromolar concentrations) increased extracellular NO by 45-55%.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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