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Study · Animal study (in vivo) · 2001

7 results

GH-releasing peptide-6 overcomes refractoriness of somatotropes to GHRH after feeding.

McMahon CD, Chapin LT, Radcliff RP, Lookingland KJ, Tucker HA

The Journal of endocrinology1 Jul 2001Cited by 7 (Europe PMC)

PMID11431156 (opens in a new tab)DOI10.1677/joe.0.1700235 (opens in a new tab)PepBankPUB-11431156
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In animals, intravenous GHRP‑6 stimulated GH secretion in a dose-dependent manner.

    In plain wordsIn animals, intravenous GHRP‑6 increased growth hormone secretion as the dose increased.

    Peptide
    GHRP-6
    Outcome
    IncreaseDose-dependent GH secretion
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1, 3 and 10 microg/kg body weight · intravenousAs given in this study.

    Source sentences

    Summary
    Initially, we determined that intravenous injection of GHRP-6 at 1, 3 and 10 microg/kg body weight (BW) stimulated secretion of GH in a dose-dependent manner.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In animals, GHRP‑6 with GHRH produced greater GH release than GHRH alone after feeding.

    In plain wordsIn animals, adding GHRP‑6 to GHRH increased growth hormone release after feeding compared with GHRH alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseCombination GH release versus GHRH after feeding
    Study

    n: not reported in source

    Comparator
    GHRH alone after feeding
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    3 microg/kg BWAs given in this study.

    Source sentences

    Summary
    However, a combination of GHRP-6 at 3 microg/kg BW and GHRH at 0.2 microg/kg BW synergistically induced an equal and massive release of GH before and after feeding that was fivefold greater than GHRH-induced release of GH after feeding.
  3. 03LabEx vivo tissueMechanism

    In bovine hypothalamic slices, GHRP‑6 stimulated GHRH secretion.

    In plain wordsIn lab tests, GHRP‑6 increased GHRH release from bovine hypothalamic tissue.

    Peptide
    GHRP-6
    Outcome
    IncreaseGHRH secretion
    Study

    bovinen: not reported in source

    hypothalamic slices
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 stimulated secretion of GHRH from bovine hypothalamic slices, but did not alter secretion of somatostatin.
  4. 04LabEx vivo tissueMechanism

    In bovine hypothalamic slices, GHRP‑6 did not alter somatostatin secretion.

    In plain wordsIn lab tests, GHRP‑6 did not change somatostatin release from bovine hypothalamic tissue.

    Peptide
    GHRP-6
    Outcome
    No significant changeSomatostatin secretion
    Study

    bovinen: not reported in source

    hypothalamic slices
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 stimulated secretion of GHRH from bovine hypothalamic slices, but did not alter secretion of somatostatin.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 05AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In animals, GHRP‑6-induced GH secretion was lower after feeding than before feeding.

    In plain wordsIn animals, GHRP‑6 produced less growth hormone after feeding than before feeding.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH secretion after versus before feeding
    Study

    n: not reported in source

    Comparator
    before feeding
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH
    22.5 ng/ml
    after feeding
    GH
    53.5 ng/ml
    before feeding

    Source sentences

    Summary
    Next, we determined that GHRP-6- and GHRH-induced secretion of GH was lower 1 h after feeding (22.5 and 20 ng/ml respectively) than 1 h before feeding (53.5 and 64.5 ng/ml respectively; pooleds.e.m.=8.5).

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 06AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In animals, GHRP‑6 with GHRH produced equal GH release before and after feeding.

    In plain wordsIn animals, GHRP‑6 with GHRH produced equal growth hormone release before and after feeding.

    Peptide
    GHRP-6
    Outcome
    No significant changeCombination GH release before versus after feeding
    Study

    n: not reported in source

    Comparator
    before feeding
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    However, a combination of GHRP-6 at 3 microg/kg BW and GHRH at 0.2 microg/kg BW synergistically induced an equal and massive release of GH before and after feeding that was fivefold greater than GHRH-induced release of GH after feeding.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 07LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In cultured somatotropes, GHRP‑6 with GHRH synergistically increased GH release.

    In plain wordsIn cells, GHRP‑6 with GHRH synergistically increased growth hormone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseSynergistic GH release in cultured somatotropes
    Study

    n: not reported in source

    cultured somatotropes
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Furthermore, the combination of GHRP-6 and GHRH synergistically increased release of GH from somatotropes cultured in vitro.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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