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Study · Case report or series · n = 1 · 2001

4 results

The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor.

Pitteloud N, Boepple PA, DeCruz S, Valkenburgh SB, Crowley WF Jr, Hayes FJ

The Journal of clinical endocrinology and metabolism1 Jun 2001Cited by 63 (Europe PMC)

PMID11397842 (opens in a new tab)DOI10.1210/jcem.86.6.7542 (opens in a new tab)PepBankPUB-11397842
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a man with fertile eunuch syndrome, sperm appeared in his ejaculate after hCG alone.

    In plain wordsIn a man with fertile eunuch syndrome, sperm appeared after hCG alone.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseSperm appearance
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 4 monthsAs given in this study (human).

    Source sentences

    Summary
    After only 4 months of treatment with hCG alone, he developed sperm in his ejaculate and his wife conceived.
    1 context sentence
    Summary · context
    Herein, we describe a 26-yr-old male with a mild phenotypic form of IHH, the fertile eunuch syndrome (IHH in the presence of normal testicular size and some degree of spermatogenesis), associated with a homozygous mutation (Gln106Arg) in the GnRH-R.
  2. 02HumanCase report or seriesEfficacy outcome

    After hCG alone in a man with fertile eunuch syndrome, his wife conceived.

    In plain wordsAfter hCG alone in a man with fertile eunuch syndrome, his wife conceived.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicablePartner conception
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 4 monthsAs given in this study (human).

    Source sentences

    Summary
    After only 4 months of treatment with hCG alone, he developed sperm in his ejaculate and his wife conceived.
    1 context sentence
    Summary · context
    Herein, we describe a 26-yr-old male with a mild phenotypic form of IHH, the fertile eunuch syndrome (IHH in the presence of normal testicular size and some degree of spermatogenesis), associated with a homozygous mutation (Gln106Arg) in the GnRH-R.

Studies that did not test the peptide alone2

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

  1. 03HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    After hCG cessation, a man with fertile eunuch syndrome showed normal adult male testosterone levels.

    In plain wordsAfter hCG stopped, a man with fertile eunuch syndrome showed normal adult male testosterone levels.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreaseTestosterone after hCG cessation
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Following cessation of hCG therapy, the patient demonstrated reversal of his hypogonadotropism as evidenced by normal adult male testosterone levels and the appearance of pulsatile luteinizing hormone secretion.
    1 context sentence
    Summary · context
    Herein, we describe a 26-yr-old male with a mild phenotypic form of IHH, the fertile eunuch syndrome (IHH in the presence of normal testicular size and some degree of spermatogenesis), associated with a homozygous mutation (Gln106Arg) in the GnRH-R.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

  2. 04HumanNot a test of hCG (human chorionic gonadotropin) aloneCase report or seriesEfficacy outcome

    After hCG cessation, a man with fertile eunuch syndrome showed pulsatile luteinizing hormone secretion.

    In plain wordsAfter hCG stopped, a man with fertile eunuch syndrome showed pulsatile luteinizing hormone secretion.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    IncreasePulsatile LH after hCG cessation
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Following cessation of hCG therapy, the patient demonstrated reversal of his hypogonadotropism as evidenced by normal adult male testosterone levels and the appearance of pulsatile luteinizing hormone secretion.
    1 context sentence
    Summary · context
    Herein, we describe a 26-yr-old male with a mild phenotypic form of IHH, the fertile eunuch syndrome (IHH in the presence of normal testicular size and some degree of spermatogenesis), associated with a homozygous mutation (Gln106Arg) in the GnRH-R.

    In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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