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Study · Animal study (in vivo) · rat · 2001

2 results

Further evidence for a significant participation of the melanocortin 4 receptor in the preovulatory prolactin surge in the rat.

Watanobe H, Yoneda M, Kakizaki Y, Kohsaka A, Suda T, Schiöth HB

Brain research bulletin1 Mar 2001Cited by 19 (Europe PMC)

PMID11397542 (opens in a new tab)DOI10.1016/s0361-9230(01)00442-7 (opens in a new tab)PepBankPUB-11397542
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In starved, steroid-primed ovariectomized female rats, MT II significantly recovered the prolactin surge.

    In plain wordsIn female rats, MT II restored the surge of the hormone prolactin.

    Peptide
    Melanotan II
    Outcome
    IncreaseProlactin surge
    Study

    ratn: not reported in source

    starved, gonadal steroid-primed ovariectomized female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1.0 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    MT II significantly recovered the surge of prolactin, but not of luteinizing hormone
    1 context sentence
    Summary · context
    intracerebroventricular administrations of 1.0 nmol of MT II (a non-selective melanocortin 3 and 4 receptor agonist) and 10 nmol of gamma(1)-melanocyte-stimulating hormone (a selective melanocortin 3 receptor agonist) on luteinizing hormone and prolactin surges in starved, gonadal steroid-primed ova…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In starved, steroid-primed ovariectomized female rats, MT II did not significantly recover the luteinizing hormone surge, although a tendency to increase was seen.

    In plain wordsIn female rats, MT II did not significantly restore the surge of luteinizing hormone, though there was a tendency to rise.

    Peptide
    Melanotan II
    Outcome
    No significant changeLuteinizing hormone surge
    Study

    ratn: not reported in source

    starved, gonadal steroid-primed ovariectomized female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1.0 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    MT II significantly recovered the surge of prolactin, but not of luteinizing hormone (although a tendency to increase was seen)
    1 context sentence
    Summary · context
    intracerebroventricular administrations of 1.0 nmol of MT II (a non-selective melanocortin 3 and 4 receptor agonist) and 10 nmol of gamma(1)-melanocyte-stimulating hormone (a selective melanocortin 3 receptor agonist) on luteinizing hormone and prolactin surges in starved, gonadal steroid-primed ova…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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