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Study · Animal study (in vivo) · rat · 2001

3 results

Novel demonstration of a physiologic/pharmacologic role of insulin-like growth factor-1 in ovulation in rats and action on cumulus oophorus.

Khamsi F, Roberge S, Wong J

Endocrine1 Mar 2001Cited by 4 (Europe PMC)

PMID11394634 (opens in a new tab)DOI10.1385/endo:14:2:175 (opens in a new tab)PepBankPUB-11394634
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In superovulated rats, LR3IGF-1 infusion further increased the ovulation rate compared with gonadotropins alone.

    In plain wordsIn rats given ovulation-stimulating hormones, an IGF-1 analogue raised the ovulation rate more than the hormones alone.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseOvulation rate
    Study

    ratn: not reported in source

    rats superovulated with gonadotropins
    Comparator
    Gonadotropins alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    We showed that the addition of LR3IGF-1 by infusion further increased the ovulation rate (statistically significant) and increased the ovarian weight in two of three strains of rats.
    1 context sentence
    Summary · context
    We studied rats that were superovulated with the use of gonadotropins.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In superovulated rats, LR3IGF-1 infusion increased ovarian weight in two of three strains compared with gonadotropins alone.

    In plain wordsIn rats given ovulation-stimulating hormones, an IGF-1 analogue raised ovary weight in two of three strains compared with the hormones alone.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseOvarian weight
    Study

    ratn: not reported in source

    rats superovulated with gonadotropins
    Comparator
    Gonadotropins alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    We showed that the addition of LR3IGF-1 by infusion further increased the ovulation rate (statistically significant) and increased the ovarian weight in two of three strains of rats.
    1 context sentence
    Summary · context
    We studied rats that were superovulated with the use of gonadotropins.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, LR3IGF-1 infusion was associated with oocytes that had fewer cumulus cells.

    In plain wordsIn rats, an IGF-1 analogue was linked to oocytes with fewer surrounding cumulus cells.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseNumber of cumulus cells per oocyte
    Study

    ratn: not reported in source

    rats superovulated with gonadotropins
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    We demonstrated that infusion of LR3IGF-1 or injection of equine chorionic gonadotropin or a combination of these two were associated with oocytes with reduced number of cumulus cells (statistically significant).
    1 context sentence
    Summary · context
    We studied rats that were superovulated with the use of gonadotropins.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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