In vitro effect of thymosin-alpha1 and interferon-alpha on Th1 and Th2 cytokine synthesis in patients with chronic hepatitis C.

Andreone P, Cursaro C, Gramenzi A, Margotti M, Ferri E, Talarico S, Biselli M, Felline F, Tuthill C, Martins E, Gasbarrini G, Bernardi M

Journal of viral hepatitis1 May 2001Cited by 34 (Europe PMC)

PMID11380797DOI10.1046/j.1365-2893.2001.00285.xPepBankPUB-11380797

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In mononuclear cells from patients with chronic hepatitis C, thymosin alpha‑1 increased IL-2 production.
In plain wordsIn lab tests on blood immune cells, thymosin alpha‑1 raised IL-2 production.
Peptide
Thymosin alpha-1
Outcome
IncreaseIL-2 production
Study
humann: not reported in source
peripheral blood mononuclear cells from untreated patients with chronic hepatitis C
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
TA1 treatment induced a significant increase in production of IL-2
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we evaluated the effects of thymosin-alpha1 (TA1), a naturally occurring thymic peptide, and interferon-alpha (IFN-alpha) on cytokine production in peripheral blood mononuclear cells from untreated patients with chronic hepatitis C.
Report a problemFND-1138079701
02LabIn vitro (cells)Mechanism
In mononuclear cells from patients with chronic hepatitis C, thymosin alpha‑1 increased synthesis of the antiviral protein 2',5'-oligoadenylate synthetase.
In plain wordsIn lab tests on blood immune cells, thymosin alpha‑1 raised levels of an antiviral protein.
Peptide
Thymosin alpha-1
Outcome
Increase2',5'-oligoadenylate synthetase synthesis
Study
humann: not reported in source
peripheral blood mononuclear cells from untreated patients with chronic hepatitis C
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
TA1 treatment induced a significant increase in production of IL-2 and 2',5'-oligoadenylate synthetase.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we evaluated the effects of thymosin-alpha1 (TA1), a naturally occurring thymic peptide, and interferon-alpha (IFN-alpha) on cytokine production in peripheral blood mononuclear cells from untreated patients with chronic hepatitis C.
Report a problemFND-1138079702
03LabIn vitro (cells)Mechanism
In mononuclear cells from patients with chronic hepatitis C, thymosin alpha‑1 decreased IL-4 production.
In plain wordsIn lab tests on blood immune cells, thymosin alpha‑1 lowered IL-4 production.
Peptide
Thymosin alpha-1
Outcome
DecreaseIL-4 production
Study
humann: not reported in source
peripheral blood mononuclear cells from untreated patients with chronic hepatitis C
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Incubation with TA1 resulted in a decrease in IL-4 and IL-10
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we evaluated the effects of thymosin-alpha1 (TA1), a naturally occurring thymic peptide, and interferon-alpha (IFN-alpha) on cytokine production in peripheral blood mononuclear cells from untreated patients with chronic hepatitis C.
Report a problemFND-1138079703
04LabIn vitro (cells)Mechanism
In mononuclear cells from patients with chronic hepatitis C, thymosin alpha‑1 decreased IL-10 production.
In plain wordsIn lab tests on blood immune cells, thymosin alpha‑1 lowered IL-10 production.
Peptide
Thymosin alpha-1
Outcome
DecreaseIL-10 production
Study
humann: not reported in source
peripheral blood mononuclear cells from untreated patients with chronic hepatitis C
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Incubation with TA1 resulted in a decrease in IL-4 and IL-10
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we evaluated the effects of thymosin-alpha1 (TA1), a naturally occurring thymic peptide, and interferon-alpha (IFN-alpha) on cytokine production in peripheral blood mononuclear cells from untreated patients with chronic hepatitis C.
Report a problemFND-1138079704
05LabIn vitro (cells)Mechanism
In mononuclear cells from patients with chronic hepatitis C, adding thymosin alpha‑1 to IFN-alpha significantly reversed the IFN-alpha-induced increase in IL-4 and IL-10, versus IFN-alpha alone.
In plain wordsIn lab tests on blood immune cells, adding thymosin alpha‑1 to interferon reversed the interferon-driven rise in IL-4 and IL-10.
Peptide
Thymosin alpha-1
Outcome
DecreaseIFN-alpha-induced IL-4 and IL-10 increase
Study
humann: not reported in source
peripheral blood mononuclear cells from untreated patients with chronic hepatitis C
Comparator
IFN-alpha alone
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Incubation with TA1 resulted in a decrease in IL-4 and IL-10, whereas IFN-alpha increased these cytokines. The addition of TA1 to IFN-alpha significantly reversed this IFN-alpha-induced increase.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we evaluated the effects of thymosin-alpha1 (TA1), a naturally occurring thymic peptide, and interferon-alpha (IFN-alpha) on cytokine production in peripheral blood mononuclear cells from untreated patients with chronic hepatitis C.
Report a problemFND-1138079705

Studies that did not test the peptide alone1

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

06LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Mechanism
In mononuclear cells from patients with chronic hepatitis C, thymosin alpha‑1 combined with IFN-alpha gave an additive or synergistic effect on the increases.
In plain wordsIn lab tests on blood immune cells, thymosin alpha‑1 together with interferon had an additive or synergistic effect.
Peptide
Thymosin alpha-1
Outcome
IncreaseIL-2 and 2',5'-oligoadenylate synthetase with thymosin alpha-1 plus IFN-alpha
Study
humann: not reported in source
peripheral blood mononuclear cells from untreated patients with chronic hepatitis C
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
incubation with TA1 and IFN-alpha together led to an additive or synergistic effect.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we evaluated the effects of thymosin-alpha1 (TA1), a naturally occurring thymic peptide, and interferon-alpha (IFN-alpha) on cytokine production in peripheral blood mononuclear cells from untreated patients with chronic hepatitis C.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-1138079706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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