Skip to content

Study · Non-randomized trial · n = 72 · 2001

5 results

Attenuation of posttraumatic muscle catabolism and osteopenia by long-term growth hormone therapy.

Hart DW, Herndon DN, Klein G, Lee SB, Celis M, Mohan S, Chinkes DL, Wolf SE

Annals of surgery1 Jun 2001Cited by 82 (Europe PMC)

PMID11371741 (opens in a new tab)DOI10.1097/00000658-200106000-00013 (opens in a new tab)PepBankPUB-11371741
Source linkPubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In severely burned children, GH increased weight gain versus placebo from 9 months, with a growing difference thereafter.

    In plain wordsIn severely burned children, GH increased weight gain more than placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseWeight gain
    Study

    n = 72

    Comparator
    Placebo
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.05 mg/kg per day · 1 year after burnAs given in this study (human).

    Source sentences

    Summary
    Growth hormone subjects gained more weight than placebo subjects at the 9-month study point; this disparity in weight gain continued to expand throughout the remainder of the study.
    2 context sentences
    Summary · context
    Seventy-two severely burned children were enrolled in a placebo-controlled double-blind trial investigating the effects of growth hormone (0.05 mg/kg per day) on muscle accretion and bone growth.
    Summary · context
    Drug or placebo treatment began on discharge from the intensive care unit and continued for 1 year after burn.
  2. 02HumanNon-randomized trialEfficacy outcome

    In severely burned children, GH increased height versus controls at 12 months.

    In plain wordsIn severely burned children, GH increased height more than controls.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseHeight
    Study

    n = 72

    Comparator
    Placebo
    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    0.05 mg/kg per day · 1 year after burnAs given in this study (human).

    Source sentences

    Summary
    Height also increased in the growth hormone group compared with controls at 12 months.
    2 context sentences
    Summary · context
    Seventy-two severely burned children were enrolled in a placebo-controlled double-blind trial investigating the effects of growth hormone (0.05 mg/kg per day) on muscle accretion and bone growth.
    Summary · context
    Drug or placebo treatment began on discharge from the intensive care unit and continued for 1 year after burn.
  3. 03HumanNon-randomized trialEfficacy outcome

    In severely burned children, GH increased lean body mass more than placebo at 6, 9, and 12 months.

    In plain wordsIn severely burned children, GH increased lean body mass more than placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseLean body mass
    Study

    n = 72

    Comparator
    Placebo
    Outcome group
    Body composition · Musculoskeletal
    Studied dose
    0.05 mg/kg per day · 1 year after burnAs given in this study (human).

    Source sentences

    Summary
    Change in lean body mass was greater in those treated with growth hormone at 6, 9, and 12 months.
    2 context sentences
    Summary · context
    Seventy-two severely burned children were enrolled in a placebo-controlled double-blind trial investigating the effects of growth hormone (0.05 mg/kg per day) on muscle accretion and bone growth.
    Summary · context
    Drug or placebo treatment began on discharge from the intensive care unit and continued for 1 year after burn.
  4. 04HumanNon-randomized trialEfficacy outcome

    In severely burned children, GH increased bone mineral content at 9 and 12 months.

    In plain wordsIn severely burned children, GH increased bone mineral content compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseBone mineral content
    Study

    n = 72

    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.05 mg/kg per day · 1 year after burnAs given in this study (human).

    Source sentences

    Summary
    Bone mineral content was increased at 9 and 12 months; this was associated with higher parathormone levels.
    2 context sentences
    Summary · context
    Seventy-two severely burned children were enrolled in a placebo-controlled double-blind trial investigating the effects of growth hormone (0.05 mg/kg per day) on muscle accretion and bone growth.
    Summary · context
    Drug or placebo treatment began on discharge from the intensive care unit and continued for 1 year after burn.
  5. 05HumanNon-randomized trialEfficacy outcome

    In severely burned children, increased bone mineral content during GH treatment was associated with higher parathormone levels.

    In plain wordsIn severely burned children, increased bone mineral content during GH treatment was linked to higher parathormone levels.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseParathormone levels
    Study

    n = 72

    Comparator
    Placebo
    Outcome group
    Bone and joint · Endocrine and hormones
    Studied dose
    0.05 mg/kg per day · 1 year after burnAs given in this study (human).

    Source sentences

    Summary
    Bone mineral content was increased at 9 and 12 months; this was associated with higher parathormone levels.
    2 context sentences
    Summary · context
    Seventy-two severely burned children were enrolled in a placebo-controlled double-blind trial investigating the effects of growth hormone (0.05 mg/kg per day) on muscle accretion and bone growth.
    Summary · context
    Drug or placebo treatment began on discharge from the intensive care unit and continued for 1 year after burn.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.