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Study · Animal study (in vivo) · mouse · 2001

14 results

FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice.

Yara S, Kawakami K, Kudeken N, Tohyama M, Teruya K, Chinen T, Awaya A, Saito A

Clinical and experimental immunology1 Apr 2001Cited by 41 (Europe PMC)

PMID11359445 (opens in a new tab)DOI10.1046/j.1365-2249.2001.01493.x (opens in a new tab)PepBankPUB-11359445
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, FTS reduced bleomycin-induced lung hydroxyproline accumulation in a dose-dependent manner.

    In plain wordsIn mice, FTS reduced lung hydroxyproline accumulation compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung hydroxyproline accumulation
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with FTS ameliorated BLM-induced fibrotic changes in a dose-dependent manner, as indicated by the reduced accumulation of hydroxyproline (HP).
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, FTS inhibited the bleomycin-induced increase in lung weight.

    In plain wordsIn mice, FTS reduced the increase in lung weight compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung weight increase
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, FTS suppressed BLM-induced cellular inflammatory response in the lungs, as evidenced by inhibition of increased lung weight, reduced accumulation of inflammatory leucocytes, including lymphocytes and neutrophils, but not macrophages, and less pronounced histopathological changes.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, FTS reduced bleomycin-induced accumulation of inflammatory leukocytes in the lungs.

    In plain wordsIn mice, FTS reduced inflammatory cell accumulation in the lungs compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung inflammatory leukocyte accumulation
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, FTS suppressed BLM-induced cellular inflammatory response in the lungs, as evidenced by inhibition of increased lung weight, reduced accumulation of inflammatory leucocytes, including lymphocytes and neutrophils, but not macrophages, and less pronounced histopathological changes.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, FTS reduced bleomycin-induced lung lymphocyte accumulation.

    In plain wordsIn mice, FTS reduced lymphocyte accumulation in the lungs compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung lymphocyte accumulation
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, FTS suppressed BLM-induced cellular inflammatory response in the lungs, as evidenced by inhibition of increased lung weight, reduced accumulation of inflammatory leucocytes, including lymphocytes and neutrophils, but not macrophages, and less pronounced histopathological changes.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, FTS reduced bleomycin-induced lung neutrophil accumulation.

    In plain wordsIn mice, FTS reduced neutrophil accumulation in the lungs compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung neutrophil accumulation
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, FTS suppressed BLM-induced cellular inflammatory response in the lungs, as evidenced by inhibition of increased lung weight, reduced accumulation of inflammatory leucocytes, including lymphocytes and neutrophils, but not macrophages, and less pronounced histopathological changes.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice, FTS did not reduce bleomycin-induced lung macrophage accumulation.

    In plain wordsIn mice, FTS did not reduce macrophage accumulation in the lungs compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeLung macrophage accumulation
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, FTS suppressed BLM-induced cellular inflammatory response in the lungs, as evidenced by inhibition of increased lung weight, reduced accumulation of inflammatory leucocytes, including lymphocytes and neutrophils, but not macrophages, and less pronounced histopathological changes.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice, FTS reduced bleomycin-induced lung histopathological changes.

    In plain wordsIn mice, FTS reduced lung tissue changes compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung histopathological changes
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, FTS suppressed BLM-induced cellular inflammatory response in the lungs, as evidenced by inhibition of increased lung weight, reduced accumulation of inflammatory leucocytes, including lymphocytes and neutrophils, but not macrophages, and less pronounced histopathological changes.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice, FTS suppressed bleomycin-induced lung TNF-alpha production.

    In plain wordsIn mice, FTS reduced lung TNF-alpha production compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung TNF-alpha production
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-alpha and IL-1beta and chemokines, MCP-1, MIP-1alpha RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice, FTS suppressed bleomycin-induced lung IL-1beta production.

    In plain wordsIn mice, FTS reduced lung IL-1beta production compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung IL-1beta production
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-alpha and IL-1beta and chemokines, MCP-1, MIP-1alpha RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice, FTS did not suppress bleomycin-induced lung MCP-1 production.

    In plain wordsIn mice, FTS did not reduce lung MCP-1 production compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeLung MCP-1 production
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-alpha and IL-1beta and chemokines, MCP-1, MIP-1alpha RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice, FTS suppressed bleomycin-induced lung MIP-1alpha production.

    In plain wordsIn mice, FTS reduced lung MIP-1alpha production compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung MIP-1alpha production
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-alpha and IL-1beta and chemokines, MCP-1, MIP-1alpha RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice, FTS suppressed bleomycin-induced lung RANTES production.

    In plain wordsIn mice, FTS reduced lung RANTES production compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung RANTES production
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-alpha and IL-1beta and chemokines, MCP-1, MIP-1alpha RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice, FTS suppressed bleomycin-induced lung MIP-2 production.

    In plain wordsIn mice, FTS reduced lung MIP-2 production compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung MIP-2 production
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-alpha and IL-1beta and chemokines, MCP-1, MIP-1alpha RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In mice, FTS suppressed bleomycin-induced lung KC production.

    In plain wordsIn mice, FTS reduced lung KC production compared with bleomycin alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLung KC production
    Study

    mousen: not reported in source

    Bleomycin-induced pulmonary fibrosis
    Comparator
    Bleomycin without FTS
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, BLM challenge increased the local synthesis of proinflammatory cytokines, TNF-alpha and IL-1beta and chemokines, MCP-1, MIP-1alpha RANTES, MIP-2 and KC, while administration of FTS suppressed the production of these cytokines, except for MCP-1.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of a nonapeptide thymic hormone, facteur thymique serique (FTS), on the murine lung fibrosis induced by intratracheal instillation of BLM.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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