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Study · Animal study (in vivo) · rat · 2001

1 result

Differential effects of insulin-like growth factor-I and gonadotropins on the proliferative activity of two subgroups of granulosa cells: cumulus oophorus and mural granulosa cells.

Khamsi F, Roberge S

Fertility and sterility1 May 2001Cited by 2 (Europe PMC)

PMID11334915 (opens in a new tab)DOI10.1016/s0015-0282(01)01695-8 (opens in a new tab)PepBankPUB-11334915
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats treated in vivo with long Arg3-IGF-I, granulosa cells showed differential responses when later exposed to FSH and LH in vitro.

    In plain wordsIn rats, cells from animals given an IGF-I analogue later responded differently to FSH and LH in a dish.

    Peptide
    IGF-1 LR3
    Outcome
    MixedGranulosa cell replication response to FSH and LH after in vivo LR3-IGFI
    Study

    ratn: not reported in source

    granulosa cells (cumulus oophorus and mural) from rats treated in vivo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Differential responses were seen in animal cells exposed to long Arg3-insulin-like growth factor in vivo and then exposed to FSH and LH in vitro.
    2 context sentences
    Summary · context
    Controlled randomized study of the action and interaction of gonadotropins and IGFI on granulosa cell replication in the rat.
    Summary · context
    The study examined the in vivo treatment with gonadotropins or an analogue of IGFI, long Arg3-insulin-like growth factor (LR3-IGFI), which does not bind to IGFI-binding proteins.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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