Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial.

Akman MA, Erden HF, Tosun SB, Bayazit N, Aksoy E, Bahceci M

Human reproduction (Oxford, England)1 May 2001Cited by 126 (Europe PMC)

PMID11331630DOI10.1093/humrep/16.5.868PepBankPUB-11331630

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanRandomized controlled trialEfficacy outcome
In poor IVF responders, the cetrorelix protocol produced lower oestradiol on HCG day than the leuprolide flare-up protocol.
In plain wordsIn poor IVF responders, oestradiol on HCG day was lower with the cetrorelix protocol than with the leuprolide protocol.
Peptide
Cetrorelix
Outcome
DecreaseOestradiol on HCG day
Study
n = 48
Comparator
Leuprolide acetate flare-up protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.25 mg daily during late follicular phaseAs given in this study (human).
Source sentences
Summary
While only the oestradiol concentrations on the day of HCG were lower in group II compared with group I, the clinical pregnancy and implantation rates among groups did not show any significance.
3 context sentences(design, population, supporting numbers)
Summary · context
group I consisted of 24 patients in 24 cycles in which leuprolide acetate (40 microg s.c. per day) was initiated on cycle day 2 followed by exogenous gonadotrophins on cycle day 3
Summary · context
group II consisted of 24 patients in 24 cycles in which ovarian stimulation included gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix, 0.25 mg daily during late follicular phase) administration.
Title · context
Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial.
Report a problemFND-1133163001
02HumanRandomized controlled trialEfficacy outcome
In poor IVF responders, clinical pregnancy rates did not differ significantly between cetrorelix and leuprolide protocols.
In plain wordsIn poor IVF responders, clinical pregnancy rates did not differ significantly between cetrorelix and leuprolide protocols.
Peptide
Cetrorelix
Outcome
No significant changeClinical pregnancy rate
Study
n = 48
Comparator
Leuprolide acetate flare-up protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.25 mg daily during late follicular phaseAs given in this study (human).
Source sentences
Summary
While only the oestradiol concentrations on the day of HCG were lower in group II compared with group I, the clinical pregnancy and implantation rates among groups did not show any significance.
3 context sentences(design, population, supporting numbers)
Summary · context
group I consisted of 24 patients in 24 cycles in which leuprolide acetate (40 microg s.c. per day) was initiated on cycle day 2 followed by exogenous gonadotrophins on cycle day 3
Summary · context
group II consisted of 24 patients in 24 cycles in which ovarian stimulation included gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix, 0.25 mg daily during late follicular phase) administration.
Title · context
Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial.
Report a problemFND-1133163002
03HumanRandomized controlled trialEfficacy outcome
In poor IVF responders, implantation rates did not differ significantly between cetrorelix and leuprolide protocols.
In plain wordsIn poor IVF responders, implantation rates did not differ significantly between cetrorelix and leuprolide protocols.
Peptide
Cetrorelix
Outcome
No significant changeImplantation rate
Study
n = 48
Comparator
Leuprolide acetate flare-up protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.25 mg daily during late follicular phaseAs given in this study (human).
Source sentences
Summary
While only the oestradiol concentrations on the day of HCG were lower in group II compared with group I, the clinical pregnancy and implantation rates among groups did not show any significance.
3 context sentences(design, population, supporting numbers)
Summary · context
group I consisted of 24 patients in 24 cycles in which leuprolide acetate (40 microg s.c. per day) was initiated on cycle day 2 followed by exogenous gonadotrophins on cycle day 3
Summary · context
group II consisted of 24 patients in 24 cycles in which ovarian stimulation included gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix, 0.25 mg daily during late follicular phase) administration.
Title · context
Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial.
Report a problemFND-1133163003

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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