High concentrations of oxytocin cause vasoconstriction by activating vasopressin V1A receptors in the isolated perfused rat kidney.

Loichot C, Krieger JP, De Jong W, Nisato D, Imbs JL, Barthelmebs M

Naunyn-Schmiedeberg's archives of pharmacology1 Apr 2001Cited by 15 (Europe PMC)

PMID11330329DOI10.1007/s002100000372PepBankPUB-11330329

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In isolated perfused kidneys of Sprague-Dawley rats, oxytocin caused concentration-dependent renal vasoconstriction only at high concentrations.
In plain wordsIn isolated rat kidneys, oxytocin narrowed blood vessels, but only at high concentrations.
Peptide
Oxytocin
Outcome
IncreaseRenal vasoconstriction in Sprague-Dawley rats
Study
ratn = 6
Isolated perfused rat kidney
Outcome group
Blood pressure · Kidney and urinary
Studied dose
concentration-dependentAs given in this study (rat).
Measurements
EC50
170 nM
Sprague-Dawley rat kidney
Source sentences
Summary
Oxytocin induced a concentration-dependent renal vasoconstriction in Sprague-Dawley rats, at rather high concentrations (EC50=170+/-39 nM, mean +/- SEM, n=6)
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were performed in vitro, in the isolated kidney perfused in an open circuit with a Tyrode's solution.
Report a problemFND-1133032901
02LabEx vivo tissueActivity measurement
In isolated Sprague-Dawley rat kidneys, the maximum oxytocin response was 44% of the vasopressin response.
In plain wordsIn isolated rat kidneys, oxytocin at most produced 44% of the vessel narrowing that vasopressin produced.
Peptide
Oxytocin
Outcome
IncreaseMaximum renal vasoconstriction relative to vasopressin
Study
ratn = 6
Isolated perfused rat kidney
Comparator
Vasopressin
Outcome group
Blood pressure · Kidney and urinary
Studied dose
Dose not stated
Measurements
Maximum response relative to vasopressin
44%
Sprague-Dawley rat kidney
Source sentences
Summary
with a maximum response amounting to 44% of that elicited by vasopressin (increase in renal vascular resistance: 11.5+/-0.9 mmHg min ml(-1) vs. 26.2+/-2.2 mmHg min ml(-1)).
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were performed in vitro, in the isolated kidney perfused in an open circuit with a Tyrode's solution.
Report a problemFND-1133032902
03LabEx vivo tissueActivity measurement
In isolated kidneys of vasopressin-deficient Brattleboro homozygous rats, oxytocin induced renal vasoconstriction with low potency and partial agonist activity.
In plain wordsIn isolated kidneys of rats that lack vasopressin, oxytocin narrowed blood vessels, but with low potency.
Peptide
Oxytocin
Outcome
IncreaseRenal vasoconstriction in Brattleboro homozygous rats
Study
ratn = 5
Isolated perfused rat kidney
Outcome group
Blood pressure · Kidney and urinary
Studied dose
Dose not stated
Measurements
EC50
59 nM
Brattleboro homozygous rat kidney
Emax
7.8 mmHg min ml(-1)
Brattleboro homozygous rat kidney
Source sentences
Summary
Oxytocin induced renal vasoconstriction in Brattleboro homozygotes and heterozygotes (EC50=59+/-12 nM and 262+/-110 nM; Emax=7.8+/-1.1 mmHg min ml(-1) and 6.9+/-0.4 mmHg min ml(-1), n=5 respectively) with characteristics similar as observed in Sprague-Dawley rats concerning partial agonist activity,…
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were performed in vitro, in the isolated kidney perfused in an open circuit with a Tyrode's solution.
Report a problemFND-1133032906
04LabEx vivo tissueActivity measurement
In isolated kidneys of Brattleboro heterozygous rats, oxytocin induced renal vasoconstriction with low potency and partial agonist activity.
In plain wordsIn isolated kidneys of heterozygous Brattleboro rats, oxytocin narrowed blood vessels, but with low potency.
Peptide
Oxytocin
Outcome
IncreaseRenal vasoconstriction in Brattleboro heterozygous rats
Study
ratn = 5
Isolated perfused rat kidney
Outcome group
Blood pressure · Kidney and urinary
Studied dose
Dose not stated
Measurements
EC50
262 nM
Brattleboro heterozygous rat kidney
Emax
6.9 mmHg min ml(-1)
Brattleboro heterozygous rat kidney
Source sentences
Summary
Oxytocin induced renal vasoconstriction in Brattleboro homozygotes and heterozygotes (EC50=59+/-12 nM and 262+/-110 nM; Emax=7.8+/-1.1 mmHg min ml(-1) and 6.9+/-0.4 mmHg min ml(-1), n=5 respectively) with characteristics similar as observed in Sprague-Dawley rats concerning partial agonist activity,…
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were performed in vitro, in the isolated kidney perfused in an open circuit with a Tyrode's solution.
Report a problemFND-1133032907
05LabEx vivo tissueMechanism
In isolated rat kidneys, the V1A receptor antagonist SR 49059 abolished oxytocin-evoked renal vasoconstriction.
In plain wordsIn isolated rat kidneys, a vasopressin V1A blocker abolished the vessel narrowing that oxytocin caused.
Peptide
Oxytocin
Outcome
DecreaseBlock of oxytocin vasoconstriction by V1A antagonist
Study
ratn: not reported in source
Isolated perfused rat kidney
Outcome group
Blood pressure · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin-evoked renal vasoconstriction was abolished by SR 49059, a selective vasopressin V1A receptor antagonist (10 nM)
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were performed in vitro, in the isolated kidney perfused in an open circuit with a Tyrode's solution.
Report a problemFND-1133032903
06LabEx vivo tissueMechanism
In isolated rat kidneys, an oxytocin receptor antagonist did not abolish oxytocin-evoked renal vasoconstriction.
In plain wordsIn isolated rat kidneys, an oxytocin receptor blocker did not stop the vessel narrowing that oxytocin caused.
Peptide
Oxytocin
Outcome
No significant changeEffect of oxytocin receptor antagonist on oxytocin vasoconstriction
Study
ratn: not reported in source
Isolated perfused rat kidney
Outcome group
Blood pressure · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
but not by d(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr-(NH2)9] vasotocin, an oxytocin receptor antagonist (10 nM).
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were performed in vitro, in the isolated kidney perfused in an open circuit with a Tyrode's solution.
Report a problemFND-1133032904
07LabEx vivo tissueMechanism
In isolated rat kidneys with the V1A antagonist SR 49059 present, oxytocin did not induce renal vasorelaxation.
In plain wordsIn isolated rat kidneys with a V1A blocker present, oxytocin did not relax the kidney blood vessels.
Peptide
Oxytocin
Outcome
No significant changeRenal vasorelaxation by oxytocin with V1A blockade
Study
ratn: not reported in source
Isolated perfused rat kidney
Outcome group
Blood pressure · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
In the presence of SR 49059, oxytocin did not induce renal vasorelaxation.
1 context sentence(design, population, supporting numbers)
Summary · context
Studies were performed in vitro, in the isolated kidney perfused in an open circuit with a Tyrode's solution.
Report a problemFND-1133032905

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

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