Skip to content

Study · Animal study (in vivo) · mouse · 2001

4 results

Restoration of immunocyte functions by thymosin alpha1 in cyclophosphamide-induced immunodeficient mice.

Ohmori H, Kamo M, Yamakoshi K, Nitta MH, Hikida M, Kanayama N

Immunopharmacology and immunotoxicology1 Feb 2001Cited by 14 (Europe PMC)

PMID11322651 (opens in a new tab)DOI10.1081/iph-100102569 (opens in a new tab)PepBankPUB-11322651
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cyclophosphamide-induced immunodeficiency, repeated thymosin alpha‑1 injection accelerated restoration of the reduced number of CD4+CD8+ thymocytes.

    In plain wordsIn mice with a weakened immune system, thymosin alpha‑1 helped restore the number of thymus T cells faster.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD4+CD8+ T cell number in thymus
    Study

    mousen: not reported in source

    cyclophosphamide-induced immunodeficiency
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30-300 microg/kg/dayAs given in this study (mouse).

    Source sentences

    Summary
    Repeated injection of 30-300 microg/kg/day of Talpha1 after CY-treatment significantly accelerated the restoration of the reduced number of CD4+CD8+ T cells in the thymus.
    1 context sentence
    Summary · context
    Here, we characterized immunostimulating properties of Talpha1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cyclophosphamide-treated mice, thymosin alpha‑1 restored the suppressed activity of helper T cells.

    In plain wordsIn mice with a weakened immune system, thymosin alpha‑1 restored the lowered activity of helper T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseHelper T cell activity
    Study

    mousen: not reported in source

    cyclophosphamide-induced immunodeficiency
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 administration was effective in restoring the suppressed activities of helper T cells and cytotoxic T cells in CY-treated mice.
    1 context sentence
    Summary · context
    Here, we characterized immunostimulating properties of Talpha1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In cyclophosphamide-treated mice, thymosin alpha‑1 restored the suppressed activity of cytotoxic T cells.

    In plain wordsIn mice with a weakened immune system, thymosin alpha‑1 restored the lowered activity of cytotoxic T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCytotoxic T cell activity
    Study

    mousen: not reported in source

    cyclophosphamide-induced immunodeficiency
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 administration was effective in restoring the suppressed activities of helper T cells and cytotoxic T cells in CY-treated mice.
    1 context sentence
    Summary · context
    Here, we characterized immunostimulating properties of Talpha1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In cyclophosphamide-treated mice, thymosin alpha‑1 stimulated the reduced activity of lymphokine-activated killer cells.

    In plain wordsIn mice with a weakened immune system, thymosin alpha‑1 raised the lowered activity of killer cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseLymphokine-activated killer cell activity
    Study

    mousen: not reported in source

    cyclophosphamide-induced immunodeficiency
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 also had stimulating effects on reduced activity of lymphokine-activated killer cells in CY-treated mice.
    1 context sentence
    Summary · context
    Here, we characterized immunostimulating properties of Talpha1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.