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Study · Non-randomized trial · n = 10 · 2001

5 results

Growth hormone/insulin-like growth factor-1 response to acute and chronic growth hormone-releasing peptide-2, growth hormone-releasing hormone 1-44NH2 and in combination in older men and women with decreased growth hormone secretion.

Bowers CY, Granda-Ayala R

Endocrine1 Feb 2001Cited by 7 (Europe PMC)

PMID11322505 (opens in a new tab)DOI10.1385/endo:14:1:079 (opens in a new tab)PepBankPUB-11322505
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In older men and women with decreased GH secretion, GHRP‑2 at 10 microg/kg sc produced a GH response about twice as high as GHRP‑2 at 1 microg/kg.

    In plain wordsIn older adults with low GH secretion, a higher GHRP‑2 dose gave about twice the GH response of a lower dose.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to GHRP-2 10 microg/kg versus 1 microg/kg
    Study

    n = 10

    Comparator
    GHRP-2 1 microg/kg
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 microg/kg · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    At a dose of 1 microg/kg GHRP-2 the GH response was essentially the same as that elicited by 1 microg/kg GHRH + 0.1 microg/kg GHRP-2 while the GH response to 10 microg/kg GHRP-2 sc was about twice as high in both men and women.
    1 context sentence
    Summary · context
    To better appreciate the interactions of GHRP-2 and GHRH 1-44NH2 on the release of GH in normal adult men and women with decreased GH secretion and low serum IGF-1 levels, a series of acute and chronic studies have been performed (n = 5 men, 5 women).
  2. 02HumanNon-randomized trialEfficacy outcome

    In older men and women with decreased GH secretion, adding GHRP‑2 0.1 microg/kg augmented the GH response to GHRH 1 microg/kg.

    In plain wordsIn older adults with low GH secretion, a small GHRP‑2 dose added to GHRH increased the GH response compared with GHRH alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to GHRH with and without low-dose GHRP-2
    Study

    n = 10

    Comparator
    GHRH 1 microg/kg alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.1 microg/kgAs given in this study (human).

    Source sentences

    Summary
    Furthermore, the finding that a low dose of 0.1 microg/kg GHRP-2 augments the GH response to 1 microg/kg GHRH is strongly against an excess secretion of SRIF.
    1 context sentence
    Summary · context
    To better appreciate the interactions of GHRP-2 and GHRH 1-44NH2 on the release of GH in normal adult men and women with decreased GH secretion and low serum IGF-1 levels, a series of acute and chronic studies have been performed (n = 5 men, 5 women).
  3. 03HumanNon-randomized trialEfficacy outcome

    In older men and women with decreased GH secretion, continuous GHRP‑2 infusion at 1 microg/kg/h increased pulsatile GH secretion after 24 h, and it stayed elevated for 30 d.

    In plain wordsIn older adults with low GH secretion, a continuous GHRP‑2 infusion raised GH pulses within a day, and they stayed higher for 30 days.

    Peptide
    GHRP-2
    Outcome
    IncreasePulsatile GH secretion during 30-day GHRP-2 infusion
    Study

    n = 10

    Comparator
    Baseline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg/h · subcutaneous · 30 daysAs given in this study (human).

    Source sentences

    Summary
    The normal pulsatile secretion of GH as well as the serum IGF-1 level was increased after 24 h and remained elevated for 30 d.
    2 context sentences
    Summary · context
    In addition, 1 microg/kg/h GHRP-2 was infused continuously sc to these subjects for 30 d.
    Summary · context
    To better appreciate the interactions of GHRP-2 and GHRH 1-44NH2 on the release of GH in normal adult men and women with decreased GH secretion and low serum IGF-1 levels, a series of acute and chronic studies have been performed (n = 5 men, 5 women).
  4. 04HumanNon-randomized trialEfficacy outcome

    In older men and women with decreased GH secretion, continuous GHRP‑2 infusion at 1 microg/kg/h increased serum IGF-1 after 24 h, and it stayed elevated for 30 d.

    In plain wordsIn older adults with low GH secretion, a continuous GHRP‑2 infusion raised IGF-1 levels within a day, and they stayed higher for 30 days.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum IGF-1 during 30-day GHRP-2 infusion
    Study

    n = 10

    Comparator
    Baseline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg/h · subcutaneous · 30 daysAs given in this study (human).

    Source sentences

    Summary
    The normal pulsatile secretion of GH as well as the serum IGF-1 level was increased after 24 h and remained elevated for 30 d.
    2 context sentences
    Summary · context
    In addition, 1 microg/kg/h GHRP-2 was infused continuously sc to these subjects for 30 d.
    Summary · context
    To better appreciate the interactions of GHRP-2 and GHRH 1-44NH2 on the release of GH in normal adult men and women with decreased GH secretion and low serum IGF-1 levels, a series of acute and chronic studies have been performed (n = 5 men, 5 women).

Studies that did not test the peptide alone1

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 05HumanNot a test of GHRP-2 aloneNon-randomized trialEfficacy outcome

    In older men and women with decreased GH secretion, the GH response to GHRP‑2 at 1 microg/kg was essentially the same as the response to GHRH 1 microg/kg plus GHRP‑2 0.1 microg/kg.

    In plain wordsIn older adults with low GH secretion, GHRP‑2 alone gave about the same GH response as GHRH plus a small GHRP‑2 dose.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH response to GHRP-2 1 microg/kg versus GHRH plus low-dose GHRP-2
    Study

    n = 10

    Comparator
    GHRH 1 microg/kg plus GHRP-2 0.1 microg/kg
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    At a dose of 1 microg/kg GHRP-2 the GH response was essentially the same as that elicited by 1 microg/kg GHRH + 0.1 microg/kg GHRP-2 while the GH response to 10 microg/kg GHRP-2 sc was about twice as high in both men and women.
    1 context sentence
    Summary · context
    To better appreciate the interactions of GHRP-2 and GHRH 1-44NH2 on the release of GH in normal adult men and women with decreased GH secretion and low serum IGF-1 levels, a series of acute and chronic studies have been performed (n = 5 men, 5 women).

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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