Skip to content

Study · Animal study (in vivo) · rat · 2001

3 results

Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin.

Tannenbaum GS, Bowers CY

Endocrine1 Feb 2001Cited by 54 (Europe PMC)

PMID11322498 (opens in a new tab)DOI10.1385/endo:14:1:021 (opens in a new tab)PepBankPUB-11322498
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male rats, GH responsiveness to GHRP‑6 varied with time, similarly to GHRH.

    In plain wordsIn rats, the growth hormone response to GHRP‑6 varied with time, like the response to GHRH.

    Peptide
    GHRP-6
    Outcome
    MixedTime-dependent GH responsiveness
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Comparison of the GH-releasing activities of the hexapeptide growth hormone-releasing peptide-6 (GHRP-6) and GHRH administered intravenously to conscious adult male rats showed that the pattern of GH responsiveness to GHRP-6 was markedly time-dependent, similar to that observed with GHRH.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, SRIF immunoneutralization reversed the blunted GH response to GHRP‑6 at trough times.

    In plain wordsIn rats, blocking natural somatostatin restored the reduced growth hormone response to GHRP‑6 at trough times.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response after SRIF immunoneutralization
    Study

    ratn: not reported in source

    conscious adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Immunoneutralization of endogenous SRIF reversed the blunted GH response to GHRP-6 at trough times, suggesting that GHRP-6 neither disrupts nor inhibits the cyclical release of endogenous hypothalamic SRIF.
    1 context sentence
    Summary · context
    Comparison of the GH-releasing activities of the hexapeptide growth hormone-releasing peptide-6 (GHRP-6) and GHRH administered intravenously to conscious adult male rats showed that the pattern of GH responsiveness to GHRP-6 was markedly time-dependent, similar to that observed with GHRH.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, anti-GHRH serum nearly abolished GH responses to GHRP‑6 regardless of administration time.

    In plain wordsIn rats, anti-GHRH serum nearly eliminated the growth hormone response to GHRP‑6 at all administration times.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response after anti-GHRH serum
    Study

    ratn: not reported in source

    conscious adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    By striking contrast, passive immunization with anti-GHRH serum virtually obliterated the GH responses to GHRP-6, irrespective of the time of administration.
    1 context sentence
    Summary · context
    Comparison of the GH-releasing activities of the hexapeptide growth hormone-releasing peptide-6 (GHRP-6) and GHRH administered intravenously to conscious adult male rats showed that the pattern of GH responsiveness to GHRP-6 was markedly time-dependent, similar to that observed with GHRH.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.