Intestinal adaptation in atrophic rat ileum is accompanied by supersensitivity to vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide and nitric oxide.

Ekelund M, Ekblad E

Scandinavian journal of gastroenterology1 Mar 2001Cited by 10 (Europe PMC)

PMID11305511DOI10.1080/00365520116742PepBankPUB-11305511

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In longitudinal muscle strips from rat ileum bypassed for one week, relaxation responses to VIP were significantly larger than in sham-operated ileum.
In plain wordsIn rat gut muscle strips in the lab, VIP caused a stronger relaxation one week after the gut was bypassed.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP-evoked relaxation in one-week bypassed ileum
Study
ratn: not reported in source
Longitudinal smooth muscle strips from rat ileum (sham-operated or bypassed)
Comparator
Sham-operated ileum
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
The amplitudes of the relaxatory responses to PACAP-27, VIP and the NO-donor S-nitroso-N-acetylpenicillamine (SNAP), but not forskolin, were significantly increased in the one-week bypassed ileum.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro experiments were carried out on longitudinal muscle strips from rat ileum having been sham-operated, one week or four weeks bypassed.
Report a problemFND-1130551101
02LabEx vivo tissueActivity measurement
In longitudinal muscle strips from rat ileum bypassed for four weeks, VIP-evoked relaxations were of the same magnitude as in sham-operated ileum.
In plain wordsIn rat gut muscle strips in the lab, VIP relaxation four weeks after bypass was the same as in sham-operated strips.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP-evoked relaxation in four-week bypassed ileum
Study
ratn: not reported in source
Longitudinal smooth muscle strips from rat ileum (sham-operated or bypassed)
Comparator
Sham-operated ileum
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
In the four-weeks bypassed ileum the VIP, PACAP-27, SNAP and forskolin evoked relaxations were of the same magnitude as those of the sham-operated.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro experiments were carried out on longitudinal muscle strips from rat ileum having been sham-operated, one week or four weeks bypassed.
Report a problemFND-1130551102
03LabEx vivo tissueMechanism
In one-week bypassed rat ileum, pre-treatment with apamin blocked the augmented relaxation responses to VIP.
In plain wordsIn rat gut muscle strips in the lab, the drug apamin blocked the stronger VIP response seen after bypass.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseApamin block of augmented VIP responses
Study
ratn: not reported in source
Longitudinal smooth muscle strips from rat ileum (sham-operated or bypassed)
Comparator
No pre-treatment
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
The augmented responses to both VIP and PACAP-27 could be blocked by pre-treatment with apamin
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro experiments were carried out on longitudinal muscle strips from rat ileum having been sham-operated, one week or four weeks bypassed.
Report a problemFND-1130551103
04LabEx vivo tissueMechanism
In one-week bypassed rat ileum, L-NAME and tetrodotoxin did not block the augmented relaxation responses to VIP.
In plain wordsIn rat gut muscle strips in the lab, L-NAME and tetrodotoxin did not block the stronger VIP response.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeL-NAME and tetrodotoxin effect on augmented VIP responses
Study
ratn: not reported in source
Longitudinal smooth muscle strips from rat ileum (sham-operated or bypassed)
Comparator
No pre-treatment
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
while N(G)-nitro-L-arginine methyl ester (L-NAME) and tetrodotoxin were ineffective.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro experiments were carried out on longitudinal muscle strips from rat ileum having been sham-operated, one week or four weeks bypassed.
Report a problemFND-1130551104
05LabEx vivo tissueMechanism
In one-week bypassed rat ileum, cross-desensitization between VIP and PACAP-27 was seen, unlike in sham-operated and four-week bypassed ileum.
In plain wordsIn rat gut muscle strips in the lab, VIP and PACAP-27 weakened each other's effect after one week of bypass only.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableCross-desensitization between VIP and PACAP-27
Study
ratn: not reported in source
Longitudinal smooth muscle strips from rat ileum (sham-operated or bypassed)
Comparator
Sham-operated and four-week bypassed ileum
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
In contrast to sham-operated and four-weeks bypassed ileum, cross-desensitization between VIP and PACAP-27 was noted after one week of bypass.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro experiments were carried out on longitudinal muscle strips from rat ileum having been sham-operated, one week or four weeks bypassed.
Report a problemFND-1130551105

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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Intestinal adaptation in atrophic rat ileum is accompanied by supersensitivity to vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide and nitric oxide.

Summary

Results from this study5

Version history

Subjects

Publication types

MeSH terms