Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome.

Spong CY, Abebe DT, Gozes I, Brenneman DE, Hill JM

The Journal of pharmacology and experimental therapeutics1 May 2001Cited by 113 (Europe PMC)

PMID11303069DOI10.1016/s0022-3565(24)29596-3PepBankPUB-11303069

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, NAP alone significantly reduced alcohol-associated fetal death.
In plain wordsIn mice, NAP alone reduced fetal death compared with alcohol alone.
Peptide
Davunetide
Outcome
DecreaseFetal death with NAP alone
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone
Outcome group
Mortality · Whole body
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment with NAP alone resulted in a significant decrease in alcohol-associated fetal death;
1 context sentence(design, population, supporting numbers)
Summary · context
Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome. Fetal demise and growth restrictions were produced after intraperiton…
Report a problemFND-1130306903
02AnimalAnimal study (in vivo)Pharmacokinetics
In mouse fetuses, 39% of total radioactivity comigrated with intact labeled NAP 60 min after administration.
In plain wordsIn mice, 39% of fetal radioactivity traveled with intact labeled NAP 60 min after administration.
Peptide
Davunetide
Outcome
Not applicableIntact peptide-associated fetal radioactivity
Study
mousen: not reported in source
Fetal alcohol syndrome
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated
Measurements
Radioactivity comigrating with intact peptide
39%
Fetus 60 min after administration
Source sentences
Summary
Bioavailability studies with [(3)H]NAPVSIPQ indicated that 39% of the total radioactivity comigrated with intact peptide in the fetus 60 min after administration.
1 context sentence(design, population, supporting numbers)
Summary · context
Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome. Fetal demise and growth restrictions were produced after intraperiton…
Report a problemFND-1130306905

Studies that did not test the peptide alone3

In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Davunetide.

03AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mice, NAP plus ADNF-9 prevented alcohol-induced fetal death, with efficacy reported for 30-min pretreatment or 1-h post-alcohol administration.
In plain wordsIn mice, NAP plus ADNF-9 pretreatment prevented fetal death compared with alcohol alone.
Peptide
Davunetide
Outcome
DecreaseFetal death with combination pretreatment
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone
Outcome group
Mortality · Whole body
Source sentences
Summary
Pretreatment with an equimolar combination of the peptides prevented the alcohol-induced fetal death and growth abnormalities.
3 context sentences(design, population, supporting numbers)
Summary · context
Peptide efficacy was evident with either 30-min pretreatment or with 1-h post-alcohol administration.
Summary · context
Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome.
Summary · context
Fetal demise and growth restrictions were produced after intraperitoneal injection of ethanol to pregnant mice during midgestation (E8).
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1130306901
04AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mice, NAP plus ADNF-9 prevented alcohol-induced growth abnormalities, with efficacy reported for 30-min pretreatment or 1-h post-alcohol administration.
In plain wordsIn mice, NAP plus ADNF-9 pretreatment prevented growth abnormalities compared with alcohol alone.
Peptide
Davunetide
Outcome
DecreaseFetal growth abnormalities with combination pretreatment
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone
Outcome group
Linear growth · Whole body
Source sentences
Summary
Pretreatment with an equimolar combination of the peptides prevented the alcohol-induced fetal death and growth abnormalities.
3 context sentences(design, population, supporting numbers)
Summary · context
Peptide efficacy was evident with either 30-min pretreatment or with 1-h post-alcohol administration.
Summary · context
Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome.
Summary · context
Fetal demise and growth restrictions were produced after intraperitoneal injection of ethanol to pregnant mice during midgestation (E8).
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1130306902
05AnimalNot a test of Davunetide aloneAnimal study (in vivo)Efficacy outcome
In mouse fetuses, NAP plus ADNF-9 prevented the alcohol-induced decrease in reduced glutathione.
In plain wordsIn mice, NAP plus ADNF-9 prevented reduced glutathione loss compared with alcohol alone.
Peptide
Davunetide
Outcome
IncreaseFetal reduced glutathione
Study
mousen: not reported in source
Fetal alcohol syndrome
Comparator
Alcohol alone
Outcome group
Oxidative stress · Whole body
Source sentences
Summary
Biochemical assessment of the fetuses indicated that the combination peptide treatment prevented the alcohol-induced decreases in reduced glutathione.
1 context sentence(design, population, supporting numbers)
Summary · context
Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome. Fetal demise and growth restrictions were produced after intraperiton…
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-1130306904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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