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Study · Not a test of the peptide alone · 2001

3 results

Clonal growth inhibition as a bioassay for thymosin alpha1: inactivation of Talpha1 by trifluroacetic acid.

Bianco-Batlles D, Naylor CW, Moshier JA, Dosescu J, Naylor PH

Cellular and molecular biology (Noisy-le-Grand, France)1 Feb 2001Cited by 3 (Europe PMC)

PMID11292250 (opens in a new tab)PepBankPUB-11292250
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In a clonal growth bioassay, treating thymosin alpha‑1 with 50% trifluoroacetic acid for 1 hr completely eliminated its activity.

    In plain wordsIn lab tests, treating thymosin alpha‑1 with a strong acid completely removed its activity.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseBioactivity after trifluoroacetic acid treatment
    Study

    humann: not reported in source

    clonal growth assay of hepatitis B transfected hepatoblastoma cells
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    but TFA completely eliminated the activity in the bioassay
    2 context sentences
    Summary · context
    Talpha1 was treated with 50% trifluoroacetic acid (TFA) for 1 hr to inactivate the peptide.
    Summary · context
    This assay was used to define the relationship between bioactivity and immunoactivity of Talpha1.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In a clonal growth bioassay, thymosin alpha‑1 heated at 90 degrees C or kept at room temperature maintained its bioactivity.

    In plain wordsIn lab tests, heating thymosin alpha‑1 did not remove its activity.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeBioactivity after heating
    Study

    humann: not reported in source

    clonal growth assay of hepatitis B transfected hepatoblastoma cells
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Talpha1 heated at 90 degrees C or at room temperature maintained its bioactivity
    1 context sentence
    Summary · context
    This assay was used to define the relationship between bioactivity and immunoactivity of Talpha1.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    Trifluoroacetic acid inactivated thymosin alpha‑1 had a retention time on reverse-phase chromatography identical to bioactive peptide but reduced immunoreactivity.

    In plain wordsIn lab tests, acid-treated thymosin alpha‑1 looked the same on a chromatography column but reacted less with antibodies.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseImmunoreactivity of TFA-inactivated peptide
    Study

    humann: not reported in source

    clonal growth assay of hepatitis B transfected hepatoblastoma cells
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The TFA inactivated Talpha1 had a retention time on reverse-phase chromatography identical to bioactive Talpha1 but reduced immunoreactivity.
    1 context sentence
    Summary · context
    This assay was used to define the relationship between bioactivity and immunoactivity of Talpha1.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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