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Study · Animal study (in vivo) · mouse · 2001

3 results

Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin.

Nakatani T, Roy G, Fujimoto N, Asahara T, Ito A

Japanese journal of cancer research : Gann1 Mar 2001Cited by 118 (Europe PMC)

PMID11267934 (opens in a new tab)PMCIDPMC5926710 (opens in a new tab)DOI10.1111/j.1349-7006.2001.tb01089.x (opens in a new tab)PepBankPUB-11267934
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In DEN-treated male mice, leuprorelin significantly reduced liver tumor multiplicity to 18.3 compared with DEN alone.

    In plain wordsIn male mice exposed to DEN, leuprorelin reduced liver tumor number compared with DEN alone.

    Peptide
    Leuprolide
    Outcome
    DecreaseLiver tumor multiplicity
    Study

    mousen: not reported in source

    DEN-treated male B6C3F(1) mice
    Comparator
    DEN only
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Measurements

    Tumor multiplicity
    18.3 tumors
    leuprorelin
    Tumor multiplicity
    60.8 tumors
    DEN only
    P value
    < 0.01
    versus DEN only

    Source sentences

    Summary
    Administration of a gonadotropin-blocking chemical, leuprorelin, to DEN-treated male mice significantly reduced the multiplicity and size of tumors to 18.3 and 2.54 mm (P < 0.01 compared to those of DEN only).
    2 context sentences
    Summary · context
    In 100% of male mice, liver tumors were observed with an average diameter of 2.72 mm and multiplicity of 60.8.
    Summary · context
    On this basis, both sexes of 12-day-old B6C3F(1) mice were injected i.p. with diethylnitrosamine (DEN) at the dose of 2.5 mg / g body weight and observed for 32 weeks (males) or 36 weeks (females).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In DEN-treated male mice, leuprorelin significantly reduced liver tumor size to 2.54 mm compared with DEN alone.

    In plain wordsIn male mice exposed to DEN, leuprorelin reduced liver tumor size compared with DEN alone.

    Peptide
    Leuprolide
    Outcome
    DecreaseLiver tumor size
    Study

    mousen: not reported in source

    DEN-treated male B6C3F(1) mice
    Comparator
    DEN only
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Measurements

    Tumor size
    2.54 mm
    leuprorelin
    Tumor size
    2.72 mm
    DEN only
    P value
    < 0.01
    versus DEN only

    Source sentences

    Summary
    Administration of a gonadotropin-blocking chemical, leuprorelin, to DEN-treated male mice significantly reduced the multiplicity and size of tumors to 18.3 and 2.54 mm (P < 0.01 compared to those of DEN only).
    2 context sentences
    Summary · context
    In 100% of male mice, liver tumors were observed with an average diameter of 2.72 mm and multiplicity of 60.8.
    Summary · context
    On this basis, both sexes of 12-day-old B6C3F(1) mice were injected i.p. with diethylnitrosamine (DEN) at the dose of 2.5 mg / g body weight and observed for 32 weeks (males) or 36 weeks (females).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In DEN-treated mice, leuprorelin administration significantly reduced serum testosterone levels.

    In plain wordsIn mice exposed to DEN, leuprorelin reduced blood testosterone levels.

    Peptide
    Leuprolide
    Outcome
    DecreaseSerum testosterone
    Study

    mousen: not reported in source

    DEN-treated male B6C3F(1) mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Serum testosterone levels were significantly reduced by orchidectomy or by leuprorelin administration.
    1 context sentence
    Summary · context
    On this basis, both sexes of 12-day-old B6C3F(1) mice were injected i.p. with diethylnitrosamine (DEN) at the dose of 2.5 mg / g body weight and observed for 32 weeks (males) or 36 weeks (females).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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