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Study · Animal study (in vivo) · rat · 2001

4 results

The effects of delta sleep-inducing peptide on the intensity of lipid peroxidation and xanthine oxidase activity in rat tissues during cold stress.

Bondarenko TI, Milyutina NP, Shustanova TA, Mikhaleva II

Neuroscience and behavioral physiology1 Jan 2001Cited by 1 (Europe PMC)

PMID11265821 (opens in a new tab)DOI10.1023/a:1026686516768 (opens in a new tab)PepBankPUB-11265821
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In intact rats, intraperitoneal DSIP decreased levels of the lipid peroxidation products diene conjugates and Schiff bases in liver and brain.

    In plain wordsIn rats, DSIP lowered markers of fat oxidation damage in liver and brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDiene conjugates and Schiff bases in liver and brain (intact rats)
    Study

    ratn: not reported in source

    Outcome group
    Oxidative stress · Whole body
    Studied dose
    12 ug/100 g · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    decreased the levels of diene conjugates and Schiff bases in liver and brain tissues
    1 context sentence
    Summary · context
    Exogenous delta sleep-inducing peptide given i.p. to intact rats at a dose of 12 microg/100 g
  2. 02AnimalAnimal study (in vivo)Mechanism

    In intact rats, intraperitoneal DSIP had no effect on xanthine oxidase activity in liver and brain.

    In plain wordsIn rats, DSIP did not change the activity of the pro-oxidant enzyme xanthine oxidase in liver and brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeXanthine oxidase activity in liver and brain (intact rats)
    Study

    ratn: not reported in source

    Outcome group
    Oxidative stress · Whole body
    Studied dose
    12 ug/100 g · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    had no effect on xanthine oxidase activity in these tissues.
    1 context sentence
    Summary · context
    Exogenous delta sleep-inducing peptide given i.p. to intact rats at a dose of 12 microg/100 g
  3. 03AnimalAnimal study (in vivo)Mechanism

    In cold-stressed rats, preliminary DSIP before three days of cold stress decreased xanthine oxidase activity in liver and brain compared with stressed rats.

    In plain wordsIn cold-stressed rats, DSIP given beforehand lowered xanthine oxidase activity in liver and brain compared with stressed rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseXanthine oxidase activity in liver and brain (cold stress)
    Study

    ratn: not reported in source

    Comparator
    Stressed rats
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated · 3 days of cold stressAs given in this study (rat).

    Source sentences

    Summary
    Preliminary administration of delta sleep-inducing peptide before three days of cold stress led to decreases in xanthine oxidase activity
    2 context sentences
    Summary · context
    in the liver and brain, as compared with values in stressed rats.
    Summary · context
    Cold stress was accompanied by increases in xanthine oxidase activity in rat liver and brain, with a consequent accumulation of diene conjugates and Schiff bases, as compared with intact animals.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In cold-stressed rats, preliminary DSIP before three days of cold stress decreased lipid peroxidation products in liver and brain compared with stressed rats.

    In plain wordsIn cold-stressed rats, DSIP given beforehand lowered fat oxidation damage markers in liver and brain compared with stressed rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLipid peroxidation products in liver and brain (cold stress)
    Study

    ratn: not reported in source

    Comparator
    Stressed rats
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated · 3 days of cold stressAs given in this study (rat).

    Source sentences

    Summary
    Preliminary administration of delta sleep-inducing peptide before three days of cold stress led to decreases in xanthine oxidase activity and lipid peroxidation products in the liver and brain, as compared with values in stressed rats.
    1 context sentence
    Summary · context
    Cold stress was accompanied by increases in xanthine oxidase activity in rat liver and brain, with a consequent accumulation of diene conjugates and Schiff bases, as compared with intact animals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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