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Study · Animal study (in vivo) · rat · 2001

12 results

Bone tissue and its mineralization in aged estrogen-depleted rats after long-term intermittent treatment with parathyroid hormone (PTH) analog SDZ PTS 893 or human PTH(1-34).

Kneissel M, Boyde A, Gasser JA

Bone1 Mar 2001Cited by 68 (Europe PMC)

PMID11248653 (opens in a new tab)DOI10.1016/s8756-3282(00)00448-8 (opens in a new tab)PepBankPUB-11248653
Publisher pagePubMedAsk about this study
Jump to 12 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, human PTH increased cancellous bone formation rates versus age-matched controls.

    In plain wordsIn rats, human PTH increased cancellous bone formation rates compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCancellous bone formation rate
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    After 36 weeks of treatment with SDZ PTS 893 or human PTH(1-34), cancellous bone formation rates and turnover were raised in all treated groups compared with age-matched controls.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, human PTH raised cancellous bone turnover versus age-matched controls.

    In plain wordsIn rats, human PTH increased cancellous bone turnover compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCancellous bone turnover
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    After 36 weeks of treatment with SDZ PTS 893 or human PTH(1-34), cancellous bone formation rates and turnover were raised in all treated groups compared with age-matched controls.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, mineral apposition rate increased with PTH dose.

    In plain wordsIn rats, higher PTH doses increased mineral apposition rate.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMineral apposition rate
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Lower doses
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    The mineral apposition rate was increasing with dose.
    2 context sentences
    Summary · context
    After 36 weeks of treatment with SDZ PTS 893 or human PTH(1-34), cancellous bone formation rates and turnover were raised in all treated groups compared with age-matched controls.
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, treatment including human PTH produced trabecular thickening.

    In plain wordsIn rats, human PTH treatment increased trabecular thickness compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    This amplified matrix synthesis led to trabecular thickening, but not to an increase in trabecular number, resulting in a crude, plate-like cancellous network with a high bone volume fraction.
    2 context sentences
    Summary · context
    After 36 weeks of treatment with SDZ PTS 893 or human PTH(1-34), cancellous bone formation rates and turnover were raised in all treated groups compared with age-matched controls.
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, treatment including human PTH did not increase trabecular number.

    In plain wordsIn rats, human PTH treatment did not increase trabecular number compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeTrabecular number
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    This amplified matrix synthesis led to trabecular thickening, but not to an increase in trabecular number, resulting in a crude, plate-like cancellous network with a high bone volume fraction.
    2 context sentences
    Summary · context
    After 36 weeks of treatment with SDZ PTS 893 or human PTH(1-34), cancellous bone formation rates and turnover were raised in all treated groups compared with age-matched controls.
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, treatment including human PTH produced a crude plate-like cancellous network with high bone volume fraction.

    In plain wordsIn rats, human PTH treatment produced a plate-like bone network with high bone volume fraction.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableCancellous architecture
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    This amplified matrix synthesis led to trabecular thickening, but not to an increase in trabecular number, resulting in a crude, plate-like cancellous network with a high bone volume fraction.
    2 context sentences
    Summary · context
    After 36 weeks of treatment with SDZ PTS 893 or human PTH(1-34), cancellous bone formation rates and turnover were raised in all treated groups compared with age-matched controls.
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH treatment formed a thick ring of new endocortical bone through modeling drifts.

    In plain wordsIn rats, PTH treatment formed a thick ring of new bone at the endocortex.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEndocortical new bone
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    Fluorochrome label-based cortical bone dynamics demonstrated that a thick ring of new bone was formed at the endocortex by activation of modeling drifts during treatment.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, subperiosteal bone formation increased with PTH dose.

    In plain wordsIn rats, higher PTH doses increased bone formation at the outer cortical surface.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubperiosteal bone formation
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Lower doses
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment-induced cortical bone formation was increased with dose at the subperiosteal and endocortical envelopes, but substantially higher at the latter.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, endocortical bone formation increased with dose and exceeded subperiosteal formation.

    In plain wordsIn rats, bone formation increased with PTH dose and was greater at the endocortex than the outer surface.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEndocortical bone formation
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Lower doses and subperiosteal envelope
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment-induced cortical bone formation was increased with dose at the subperiosteal and endocortical envelopes, but substantially higher at the latter.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, PTH treatment elevated intracortical turnover near the endocortex.

    In plain wordsIn rats, PTH treatment increased bone turnover near the endocortex compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseIntracortical turnover
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    Intracortical bone turnover was elevated near the endocortex.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, bone mineralization remained undisturbed in all compartments during PTH treatment.

    In plain wordsIn rats, bone mineralization remained undisturbed during PTH treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone mineralization
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bone mineralization was undisturbed in all compartments.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, the average degree of mineralization decreased slightly during PTH treatment.

    In plain wordsIn rats, average bone mineralization decreased slightly during PTH treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseAverage degree of mineralization
    Study

    ratn: not reported in source

    Aged ovariectomized rats
    Comparator
    Age-matched vehicle controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25, 50, or 100 microg/kg · 36 weeksAs given in this study (rat).

    Source sentences

    Summary
    The average degree of mineralization was lowered slightly, reflecting the increased portion of new bone formed during treatment.
    1 context sentence
    Summary · context
    We ovariectomized (ovx) 1-year-old rats with the exception of a baseline and a sham-operated group. Twelve weeks later, a 36 week treatment with PTH analog SDZ PTS 893 (12.5, 25, 50, 100 microg/kg), human PTH(1-34) (25, 50, 100 microg/kg), or vehicle (ovx, sham) was initiated. Bone dynamics, structu…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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