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Study · In vitro (cells) · chicken · 2001

4 results

Evidence for the direct action of thymulin on avian NK cells.

Merlino PG, Marsh JA

Developmental and comparative immunology1 May 2001Cited by 14 (Europe PMC)

PMID11246073 (opens in a new tab)DOI10.1016/s0145-305x(00)00063-x (opens in a new tab)PepBankPUB-11246073
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In K and SLD chicken splenocytes, thymulin enhanced NK activity after CD4 depletion.

    In plain wordsIn chicken cells, thymulin increased NK activity after CD4 cell depletion.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseNK activity after CD4 depletion
    Study

    chickenn: not reported in source

    K and SLD chicken splenocyte preparations
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · overnightAs given in this study (chicken).

    Source sentences

    Summary
    Thymulin continued to enhance NK activity following CD4 or CD3 cell depletion, but not after CD8 or CD8 and CD4 cell depletion.
    2 context sentences
    Summary · context
    Although the control K-strain had higher overall NK cell-mediated cytotoxicity than the thymulin-deficient SLD-strain, the following trends were seen in both strains.
    Summary · context
    Specific cell population depletions were done in K and SLD chicken splenocyte preparations using anti-CD3, CD4, and CD8 monoclonal antibodies and secondary complement-fixing polyclonal antibodies. The remaining cells were incubated overnight with in vitro treatments of thymulin and IFN-gamma, either…
  2. 02LabIn vitro (cells)Activity measurement

    In K and SLD chicken splenocytes, thymulin enhanced NK activity after CD3 depletion.

    In plain wordsIn chicken cells, thymulin increased NK activity after CD3 cell depletion.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseNK activity after CD3 depletion
    Study

    chickenn: not reported in source

    K and SLD chicken splenocyte preparations
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · overnightAs given in this study (chicken).

    Source sentences

    Summary
    Thymulin continued to enhance NK activity following CD4 or CD3 cell depletion, but not after CD8 or CD8 and CD4 cell depletion.
    2 context sentences
    Summary · context
    Although the control K-strain had higher overall NK cell-mediated cytotoxicity than the thymulin-deficient SLD-strain, the following trends were seen in both strains.
    Summary · context
    Specific cell population depletions were done in K and SLD chicken splenocyte preparations using anti-CD3, CD4, and CD8 monoclonal antibodies and secondary complement-fixing polyclonal antibodies. The remaining cells were incubated overnight with in vitro treatments of thymulin and IFN-gamma, either…
  3. 03LabIn vitro (cells)Activity measurement

    In K and SLD chicken splenocytes, thymulin did not enhance NK activity after CD8 depletion.

    In plain wordsIn chicken cells, thymulin did not increase NK activity after CD8 cell depletion.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeNK activity after CD8 depletion
    Study

    chickenn: not reported in source

    K and SLD chicken splenocyte preparations
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · overnightAs given in this study (chicken).

    Source sentences

    Summary
    Thymulin continued to enhance NK activity following CD4 or CD3 cell depletion, but not after CD8 or CD8 and CD4 cell depletion.
    2 context sentences
    Summary · context
    Although the control K-strain had higher overall NK cell-mediated cytotoxicity than the thymulin-deficient SLD-strain, the following trends were seen in both strains.
    Summary · context
    Specific cell population depletions were done in K and SLD chicken splenocyte preparations using anti-CD3, CD4, and CD8 monoclonal antibodies and secondary complement-fixing polyclonal antibodies. The remaining cells were incubated overnight with in vitro treatments of thymulin and IFN-gamma, either…
  4. 04LabIn vitro (cells)Activity measurement

    In K and SLD chicken splenocytes, thymulin did not enhance NK activity after combined CD8 and CD4 depletion.

    In plain wordsIn chicken cells, thymulin did not increase NK activity after combined CD8 and CD4 cell depletion.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeNK activity after combined CD8 and CD4 depletion
    Study

    chickenn: not reported in source

    K and SLD chicken splenocyte preparations
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · overnightAs given in this study (chicken).

    Source sentences

    Summary
    Thymulin continued to enhance NK activity following CD4 or CD3 cell depletion, but not after CD8 or CD8 and CD4 cell depletion.
    2 context sentences
    Summary · context
    Although the control K-strain had higher overall NK cell-mediated cytotoxicity than the thymulin-deficient SLD-strain, the following trends were seen in both strains.
    Summary · context
    Specific cell population depletions were done in K and SLD chicken splenocyte preparations using anti-CD3, CD4, and CD8 monoclonal antibodies and secondary complement-fixing polyclonal antibodies. The remaining cells were incubated overnight with in vitro treatments of thymulin and IFN-gamma, either…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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