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Study · Animal study (in vivo) · rat · 2001

2 results

Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia.

Bashkatova VG, Koshelev VB, Fadyukova OE, Alexeev AA, Vanin AF, Rayevsky KS, Ashmarin IP, Armstrong DM

Brain research1 Mar 2001Cited by 20 (Europe PMC)

PMID11245825 (opens in a new tab)DOI10.1016/s0006-8993(00)03324-2 (opens in a new tab)PepBankPUB-11245825
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with incomplete global ischemia, Semax abated the rise in nitric oxide in the cerebral cortex.

    In plain wordsIn rats with reduced brain blood flow, Semax limited the rise in nitric oxide in the brain cortex.

    Peptide
    Semax
    Outcome
    DecreaseNitric oxide rise after global ischemia
    Study

    ratn: not reported in source

    Incomplete global ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax proved to be highly effective in abating the rise in nitric oxide
    1 context sentence
    Summary · context
    In brief, nitric oxide and indices of lipid peroxidation were elevated following global ischemia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with incomplete global ischemia, Semax restored neurologic functioning.

    In plain wordsIn rats with reduced brain blood flow, Semax restored nerve function.

    Peptide
    Semax
    Outcome
    IncreaseNeurological function after global ischemia
    Study

    ratn: not reported in source

    Incomplete global ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax proved to be highly effective in abating the rise in nitric oxide and restoring neurologic functioning.
    1 context sentence
    Summary · context
    In brief, nitric oxide and indices of lipid peroxidation were elevated following global ischemia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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