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Study · Not a test of the peptide alone · 2001

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Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.

Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, Kawasumi M, Hiraki T, Kita Y, Terashita K, Kouyama K, Nishimoto I

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Mar 2001Cited by 61 (Europe PMC)

PMID11245675 (opens in a new tab)PMCIDPMC6762606 (opens in a new tab)DOI10.1523/jneurosci.21-06-01902.2001 (opens in a new tab)PepBankPUB-11245675
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 01LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Efficacy outcome

    In cell systems, IGFBP-3 did not block des(1‑3)IGF-I protection against V642I-APP toxicity, although it blocked IGF-I protection.

    In plain wordsIn cells, IGFBP-3 did not block des(1‑3)IGF-I protection against mutant APP toxicity, although it blocked IGF-I protection.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeProtection against V642I-APP toxicity
    Study

    n: not reported in source

    Comparator
    Des(1-3)IGF-I protection without IGFBP-3
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    IGFBP-3 blocked this action of IGF-I, but not of des(1-3)IGF-I, which was as active as IGF-I in the presence of IGFBP-3.
    1 context sentence
    Summary · context
    Here, we examined whether IGF-I exerts protective activity against cell death induced by a familial AD (FAD)-linked mutant of amyloid precursor protein (APP), and we found that IGF-I protected cells from toxicity of FAD-associated V642I mutant of APP in multiple cell systems.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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