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Study · Randomized controlled trial · n = 213 · 2000

15 results

A comparative study of the acceptability and effect of goserelin and nafarelin on endometriosis.

Bergqvist A

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1 Dec 2000Cited by 20 (Europe PMC)

PMID11228063 (opens in a new tab)DOI10.3109/09513590009167714 (opens in a new tab)PepBankPUB-11228063
Publisher pagePubMedAsk about this study
Jump to 15 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In women with endometriosis, adverse events did not differ significantly between goserelin and nafarelin.

    In plain wordsIn women with endometriosis, adverse events did not differ significantly between goserelin and nafarelin.

    Peptide
    Goserelin
    Outcome
    No significant changeAdverse events
    Study

    n = 213

    Comparator
    nafarelin
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    There were no statistically significant differences between the groups, either in adverse events or in bleeding.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  2. 02HumanRandomized controlled trialSafety outcome

    In women with endometriosis, adverse events did not differ significantly between nafarelin and goserelin.

    In plain wordsIn women with endometriosis, adverse events did not differ significantly between nafarelin and goserelin.

    Peptide
    Nafarelin
    Outcome
    No significant changeAdverse events
    Study

    n = 213

    Comparator
    goserelin
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    There were no statistically significant differences between the groups, either in adverse events or in bleeding.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women with endometriosis, bleeding did not differ significantly between goserelin and nafarelin.

    In plain wordsIn women with endometriosis, bleeding did not differ significantly between goserelin and nafarelin.

    Peptide
    Goserelin
    Outcome
    No significant changeBleeding
    Study

    n = 213

    Comparator
    nafarelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    There were no statistically significant differences between the groups, either in adverse events or in bleeding.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women with endometriosis, bleeding did not differ significantly between nafarelin and goserelin.

    In plain wordsIn women with endometriosis, bleeding did not differ significantly between nafarelin and goserelin.

    Peptide
    Nafarelin
    Outcome
    No significant changeBleeding
    Study

    n = 213

    Comparator
    goserelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    There were no statistically significant differences between the groups, either in adverse events or in bleeding.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In women with endometriosis, endometriosis score change did not differ between goserelin and nafarelin.

    In plain wordsIn women with endometriosis, endometriosis score change did not differ between goserelin and nafarelin.

    Peptide
    Goserelin
    Outcome
    No significant changeEndometriosis score change
    Study

    n = 213

    Comparator
    nafarelin
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    There were no correlations between location, lesion size or type of lesion, and symptom score in either group, or between treatments with regard to change in endometriosis score.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In women with endometriosis, endometriosis score change did not differ between nafarelin and goserelin.

    In plain wordsIn women with endometriosis, endometriosis score change did not differ between nafarelin and goserelin.

    Peptide
    Nafarelin
    Outcome
    No significant changeEndometriosis score change
    Study

    n = 213

    Comparator
    goserelin
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    There were no correlations between location, lesion size or type of lesion, and symptom score in either group, or between treatments with regard to change in endometriosis score.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  7. 07HumanRandomized controlled trialSafety outcome

    In women with endometriosis, nasal irritation occurred in both groups, mostly with nafarelin rather than goserelin.

    In plain wordsIn women with endometriosis, nasal irritation occurred in both groups, mostly with nafarelin rather than goserelin.

    Peptide
    Goserelin
    Outcome
    DecreaseNasal mucosal irritation
    Study

    n: not reported in source

    Comparator
    nafarelin
    Outcome group
    Adverse events · Respiratory
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Local irritation in the nasal mucosa was reported in both groups, mostly in the nafarelin-treated group.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  8. 08HumanRandomized controlled trialSafety outcome

    In women with endometriosis, nasal irritation occurred mostly with nafarelin rather than goserelin.

    In plain wordsIn women with endometriosis, nasal irritation occurred mostly with nafarelin rather than goserelin.

    Peptide
    Nafarelin
    Outcome
    IncreaseNasal mucosal irritation
    Study

    n: not reported in source

    Comparator
    goserelin
    Outcome group
    Adverse events · Respiratory
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Local irritation in the nasal mucosa was reported in both groups, mostly in the nafarelin-treated group.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  9. 09HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, red and black lesion proportions decreased during goserelin treatment, as in the nafarelin group.

    In plain wordsIn women with endometriosis, red and black lesion proportions decreased during goserelin treatment, as with nafarelin.

    Peptide
    Goserelin
    Outcome
    DecreaseRed and black lesion proportions
    Study

    n = 113

    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    In both groups, the percentage of red and black lesions was reduced while the proportion of white lesions increased.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  10. 10HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, white lesion proportion increased during goserelin treatment, as in the nafarelin group.

    In plain wordsIn women with endometriosis, white lesion proportion increased during goserelin treatment, as with nafarelin.

    Peptide
    Goserelin
    Outcome
    IncreaseWhite lesion proportion
    Study

    n = 113

    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    In both groups, the percentage of red and black lesions was reduced while the proportion of white lesions increased.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  11. 11HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, pain scores decreased significantly during goserelin treatment, as in the nafarelin group.

    In plain wordsIn women with endometriosis, pain scores decreased significantly during goserelin treatment, as with nafarelin.

    Peptide
    Goserelin
    Outcome
    DecreasePain score
    Study

    n = 113

    Outcome group
    Pain · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    The pain score was significantly reduced in both groups.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  12. 12HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, red and black lesion proportions decreased during nafarelin treatment, as in the goserelin group.

    In plain wordsIn women with endometriosis, red and black lesion proportions decreased during nafarelin treatment, as with goserelin.

    Peptide
    Nafarelin
    Outcome
    DecreaseRed and black lesion proportions
    Study

    n = 100

    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    In both groups, the percentage of red and black lesions was reduced while the proportion of white lesions increased.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  13. 13HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, white lesion proportion increased during nafarelin treatment, as in the goserelin group.

    In plain wordsIn women with endometriosis, white lesion proportion increased during nafarelin treatment, as with goserelin.

    Peptide
    Nafarelin
    Outcome
    IncreaseWhite lesion proportion
    Study

    n = 100

    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    In both groups, the percentage of red and black lesions was reduced while the proportion of white lesions increased.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  14. 14HumanNon-randomized trialEfficacy outcome

    In women with endometriosis, pain scores decreased significantly during nafarelin treatment, as in the goserelin group.

    In plain wordsIn women with endometriosis, pain scores decreased significantly during nafarelin treatment, as with goserelin.

    Peptide
    Nafarelin
    Outcome
    DecreasePain score
    Study

    n = 100

    Outcome group
    Pain · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    The pain score was significantly reduced in both groups.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.
  15. 15HumanNon-randomized trialSafety outcome

    In women with endometriosis, goserelin recipients reported local injection-site symptoms.

    In plain wordsIn women with endometriosis, goserelin recipients reported local injection-site symptoms.

    Peptide
    Goserelin
    Outcome
    Direction not reportedInjection-site symptoms
    Study

    n: not reported in source

    Outcome group
    Adverse events · Skin and wound
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    The goserelin-treated group also reported local symptoms at the injection site.
    1 context sentence
    Summary · context
    The effects of goserelin and nafarelin were compared in a prospective, randomized, open, parallel study of 6 months' treatment of 252 women with symptomatic, laparoscopically proven endometriosis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:36 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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