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Study · Animal study (in vivo) · mouse · 2001

9 results

[Effect of pineal peptide on parameters of the biological age and life span in mice].

Anisimov VN, Khavinson VKh, Zavarzina NIu, Zabezhinskiĭ MA, Zimina OA, Popovich IG, Shtylik AV, Arutiunian AV, Oparina TI, Prokopenko VM

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Jan 2001Cited by 1 (Europe PMC)

PMID11227856 (opens in a new tab)PepBankPUB-11227856
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, long-term epithalon injection did not affect body weight.

    In plain wordsIn mice, epithalon did not change body weight.

    Peptide
    Epitalon
    Outcome
    No significant changeBody weight
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    The drug failed to affect the body weight or food consumption, physical activity or behavioural parameters.
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, long-term epithalon injection did not affect food consumption.

    In plain wordsIn mice, epithalon did not change how much they ate.

    Peptide
    Epitalon
    Outcome
    No significant changeFood consumption
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    The drug failed to affect the body weight or food consumption, physical activity or behavioural parameters.
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, long-term epithalon injection did not affect physical activity.

    In plain wordsIn mice, epithalon did not change physical activity.

    Peptide
    Epitalon
    Outcome
    No significant changePhysical activity
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Exercise and physical function · Whole body
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    The drug failed to affect the body weight or food consumption, physical activity or behavioural parameters.
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, long-term epithalon injection did not affect behavioural parameters.

    In plain wordsIn mice, epithalon did not change behaviour measures.

    Peptide
    Epitalon
    Outcome
    No significant changeBehavioural parameters
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    The drug failed to affect the body weight or food consumption, physical activity or behavioural parameters.
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, epithalon slowed the age-related switching off of the estrus function.

    In plain wordsIn mice, epithalon slowed the age-related loss of the estrus cycle.

    Peptide
    Epitalon
    Outcome
    DecreaseAge-related loss of estrus function
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    slowed down the age-related switching off of the estrus function
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, epithalon decreased body temperature.

    In plain wordsIn mice, epithalon lowered body temperature.

    Peptide
    Epitalon
    Outcome
    DecreaseBody temperature
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    decreased body temperature, decelerated free redical processes, prolonged the mice life span with an accompanying drop in spontaneous tumour incidence.
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, epithalon decelerated free radical processes.

    In plain wordsIn mice, epithalon slowed free radical processes.

    Peptide
    Epitalon
    Outcome
    DecreaseFree radical processes
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Oxidative stress · Aging and longevity
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    decelerated free redical processes
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, epithalon prolonged the life span.

    In plain wordsIn mice, epithalon extended life span.

    Peptide
    Epitalon
    Outcome
    IncreaseLife span
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    prolonged the mice life span
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, epithalon was accompanied by a drop in spontaneous tumour incidence.

    In plain wordsIn mice, epithalon went with fewer spontaneous tumours.

    Peptide
    Epitalon
    Outcome
    DecreaseSpontaneous tumour incidence
    Study

    mousen: not reported in source

    female CBA mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · subcutaneous · from age 6 months until deathAs given in this study (mouse).

    Source sentences

    Summary
    drop in spontaneous tumour incidence.
    1 context sentence
    Summary · context
    Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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