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Study · In vitro (cells) · 2000

3 results

Preliminary study on the relationship between cAMP level and gsp expression in cultured human pituitary somatotrophinomas.

Lei T, Liu Q, Li L, Zhang L, Shu K, Xue D

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao1 Jan 2000Cited by 2 (Europe PMC)

PMID11215052 (opens in a new tab)DOI10.1007/bf02886994 (opens in a new tab)PepBankPUB-11215052
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured human gsp-positive somatotrophinomas, GHRP‑6 significantly stimulated cAMP production.

    In plain wordsIn cells from human gsp-positive pituitary tumors, GHRP‑6 increased cAMP production.

    Peptide
    GHRP-6
    Outcome
    IncreasecAMP production
    Study

    humann = 2

    cultured pituitary somatotrophinomas
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was found that GHRP-6 exerted significant stimulatory effect on cAMP production by 2 gsp-positive tumors and no effect on the gsp-negative tumors.
  2. 02LabIn vitro (cells)Mechanism

    In cultured human gsp-negative somatotrophinomas, GHRP‑6 did not affect cAMP production.

    In plain wordsIn cells from human gsp-negative pituitary tumors, GHRP‑6 did not affect cAMP production.

    Peptide
    GHRP-6
    Outcome
    No significant changecAMP production
    Study

    humann: not reported in source

    cultured pituitary somatotrophinomas
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was found that GHRP-6 exerted significant stimulatory effect on cAMP production by 2 gsp-positive tumors and no effect on the gsp-negative tumors.
  3. 03LabIn vitro (cells)Mechanism

    In cultured human tumors without gsp oncogenes, GHRP‑6 enhanced GHRH-induced cAMP production.

    In plain wordsIn cells from human tumors without gsp oncogenes, adding GHRP‑6 increased cAMP production more than GHRH alone.

    Peptide
    GHRP-6
    Outcome
    IncreasecAMP production
    Study

    humann: not reported in source

    cultured pituitary somatotrophinomas
    Comparator
    GHRH alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 could enhance the stimulation of cAMP production induced by GHRH in tumor without gsp oncogenes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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