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Study · In vitro (cells) · 2001

5 results

Insulin-like growth factors I and II induce cell death in Wilms's tumour cells.

Granérus M, Johannisson A, Ekblom P, Engström W

Molecular pathology : MP1 Feb 2001Cited by 8 (Europe PMC)

PMID11212886 (opens in a new tab)PMCIDPMC1186997 (opens in a new tab)DOI10.1136/mp.54.1.30 (opens in a new tab)PepBankPUB-11212886
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In WCCS-1 cells, Des(1‑3)IGF-I induced cell death with potency equal to IGFs.

    In plain wordsIn cells, Des(1‑3)IGF-I caused cell death with potency equal to IGFs.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeCell death potency
    Study

    n: not reported in source

    WCCS-1 Wilms's tumour cells
    Comparator
    IGF-I and IGF-II
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, this peptide was equally potent in inducing cell death.
    2 context sentences
    Summary · context
    To study the effects of insulin-like growth factors (IGFs) on the growth phenotype of a Wilms's tumour cell line (WCCS-1).
    Summary · context
    To exclude any influences of the IGF binding proteins (IGFBPs), all results were repeated with Des(1-3)IGF-I, which is unable to bind to any of the IGFBPs.
  2. 02LabIn vitro (cells)Activity measurement

    In WCCS-1 cells, Des(1‑3)IGF-I reproduced the decline in cell numbers, greatest on the fifth to sixth day.

    In plain wordsIn cells, Des(1‑3)IGF-I reproduced the decline in cell numbers.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseCell numbers
    Study

    n: not reported in source

    WCCS-1 Wilms's tumour cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell numbers decreased most dramatically on the fifth to sixth day after growth factor addition.
    2 context sentences
    Summary · context
    To exclude any influences of the IGF binding proteins (IGFBPs), all results were repeated with Des(1-3)IGF-I, which is unable to bind to any of the IGFBPs.
    Summary · context
    To study the effects of insulin-like growth factors (IGFs) on the growth phenotype of a Wilms's tumour cell line (WCCS-1).
  3. 03LabIn vitro (cells)Activity measurement

    In WCCS-1 cells, Des(1‑3)IGF-I reproduced apoptosis detected by annexin-V staining.

    In plain wordsIn cells, Des(1‑3)IGF-I reproduced apoptosis.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseApoptosis
    Study

    n: not reported in source

    WCCS-1 Wilms's tumour cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The occurrence of apoptosis as well as necrosis was confirmed by annexin-V staining of cell cultures.
    2 context sentences
    Summary · context
    To exclude any influences of the IGF binding proteins (IGFBPs), all results were repeated with Des(1-3)IGF-I, which is unable to bind to any of the IGFBPs.
    Summary · context
    To study the effects of insulin-like growth factors (IGFs) on the growth phenotype of a Wilms's tumour cell line (WCCS-1).
  4. 04LabIn vitro (cells)Activity measurement

    In WCCS-1 cells, Des(1‑3)IGF-I reproduced necrosis detected by annexin-V staining.

    In plain wordsIn cells, Des(1‑3)IGF-I reproduced necrosis.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseNecrosis
    Study

    n: not reported in source

    WCCS-1 Wilms's tumour cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The occurrence of apoptosis as well as necrosis was confirmed by annexin-V staining of cell cultures.
    2 context sentences
    Summary · context
    To exclude any influences of the IGF binding proteins (IGFBPs), all results were repeated with Des(1-3)IGF-I, which is unable to bind to any of the IGFBPs.
    Summary · context
    To study the effects of insulin-like growth factors (IGFs) on the growth phenotype of a Wilms's tumour cell line (WCCS-1).
  5. 05LabIn vitro (cells)Activity measurement

    In WCCS-1 cells, Des(1‑3)IGF-I reproduced comparable S-phase indices in exposed and unexposed cells.

    In plain wordsIn cells, S-phase indices remained comparable with and without Des(1‑3)IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeS-phase indices
    Study

    n: not reported in source

    WCCS-1 Wilms's tumour cells
    Comparator
    Unexposed cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    S-phase indices were comparable, irrespective of whether the cells were exposed to IGFs or not, which suggests that WCCS-1 cells undergo cell death at random during the cell cycle rather that from the prereplicative phase.
    2 context sentences
    Summary · context
    To exclude any influences of the IGF binding proteins (IGFBPs), all results were repeated with Des(1-3)IGF-I, which is unable to bind to any of the IGFBPs.
    Summary · context
    To study the effects of insulin-like growth factors (IGFs) on the growth phenotype of a Wilms's tumour cell line (WCCS-1).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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