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Study · Measured the body's own peptide · 2001

3 results

Cutting edge: is vasoactive intestinal peptide a type 2 cytokine?

Delgado M, Ganea D

Journal of immunology (Baltimore, Md. : 1950)1 Mar 2001Cited by 66 (Europe PMC)

PMID11207237 (opens in a new tab)DOI10.4049/jimmunol.166.5.2907 (opens in a new tab)PepBankPUB-11207237
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In immunized non-transgenic mice, serum VIP was significantly raised in hosts that received Th2 transgenic cells but not in hosts that received Th1 cells.

    In plain wordsIn mice, the body's own VIP in the blood was higher after Th2 cells were transferred, but not after Th1 cells.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseSerum VIP after transfer of Th2 cells
    Study

    mousen: not reported in source

    Non-transgenic syngeneic mice that received transferred Th2 or Th1 transgenic cells
    Comparator
    Th1 transgenic cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Following immunization with the specific Ag, significant levels of VIP are present in the serum of syngeneic, non-Tg hosts that receive Th2, but not Th1 Tg cells.
    1 context sentence
    Summary · context
    Here we investigate whether T cell subsets differentially express VIP.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In immunized non-transgenic mice, Th2 transgenic cells recovered after specific antigen, but not after an irrelevant antigen, expressed intracellular VIP.

    In plain wordsIn mice, Th2 cells made the body's own VIP after the specific antigen but not after an irrelevant antigen.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseIntracellular VIP in recovered Th2 cells
    Study

    mousen: not reported in source

    Non-transgenic syngeneic mice that received transferred Th2 transgenic cells
    Comparator
    Irrelevant antigen
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Th2 Tg cells recovered from the non-Tg hosts immunized with the specific Ag, but not with an irrelevant Ag, express intracellular VIP.
    1 context sentence
    Summary · context
    Here we investigate whether T cell subsets differentially express VIP.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Other

    In antigen-stimulated T cells from TCR transgenic mice, Th2 and T2 cells, but not Th1 and T1 cells, expressed VIP mRNA and protein and secreted VIP.

    In plain wordsIn mouse T cells in the lab, Th2 and T2 cells made and released the body's own VIP; Th1 and T1 cells did not.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP mRNA, protein and secretion by T cell subsets
    Study

    mousen: not reported in source

    Antigen-stimulated Th1, Th2, T1 and T2 cells from TCR transgenic mice
    Comparator
    Th1 and T1 cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Our studies indicate that, upon specific Ag stimulation, Th2 and T2 cells, but not Th1 and T1 cells derived from TCR transgenic (Tg) mice, express VIP mRNA and protein, and secrete VIP.
    1 context sentence
    Summary · context
    Here we investigate whether T cell subsets differentially express VIP.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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