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Study · In vitro (cells) · 2000

4 results

Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress.

Andreeva NA, Stel'mashuk EV, Isaev NK, Ostrovskaya RU, Gudasheva TA, Viktorov IV

Bulletin of experimental biology and medicine1 Oct 2000Cited by 10 (Europe PMC)

PMID11177296 (opens in a new tab)DOI10.1023/a:1002828707337 (opens in a new tab)PepBankPUB-11177296
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cerebellar granule cell cultures, GVS-111 protected against damage modeled with argon anoxia and glucose deprivation.

    In plain wordsIn cells, GVS-111 protected against damage from oxygen and glucose deprivation.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseIschemic cell damage
    Study

    n: not reported in source

    Cerebellar granule cell cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protective effect of peptide piracetam analogue GVS-111 was demonstrated.
    1 context sentence
    Summary · context
    Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cerebellar granule cell cultures, GVS-111 prevented glutamate-induced neurodegeneration.

    In plain wordsIn cells, GVS-111 prevented glutamate-induced nerve cell damage.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseGlutamate-induced neurodegeneration
    Study

    n: not reported in source

    Cerebellar granule cell cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress.
    1 context sentence
    Summary · context
    Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cerebellar granule cell cultures, GVS-111 prevented oxidative stress-induced neurodegeneration.

    In plain wordsIn cells, GVS-111 prevented nerve cell damage from oxidative stress.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseOxidative stress-induced neurodegeneration
    Study

    n: not reported in source

    Cerebellar granule cell cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress.
    1 context sentence
    Summary · context
    Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cerebellar granule cell cultures, GVS-111 attenuated glutamate neurocytotoxicity, whereas piracetam did not.

    In plain wordsIn cells, GVS-111 reduced glutamate toxicity, whereas piracetam did not.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseGlutamate neurocytotoxicity versus piracetam
    Study

    n: not reported in source

    Cerebellar granule cell cultures
    Comparator
    Piracetam
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate.
    1 context sentence
    Summary · context
    Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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