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Study · Animal study (in vivo) · rat · 2000

4 results

Effect of Semax on homeostasis of gastric mucosa in albino rats.

Zhuikova SE, Smirnova EA, Bakaeva ZV, Samonina GE, Ashmarin IP

Bulletin of experimental biology and medicine1 Sept 2000Cited by 5 (Europe PMC)

PMID11177268 (opens in a new tab)DOI10.1023/a:1015366229006 (opens in a new tab)PepBankPUB-11177268
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In albino rats, Semax at 50 microg/kg given 1 h before ethanol or immobilization stress protected the gastric mucosa from damage.

    In plain wordsIn rats, Semax given before ethanol or stress protected the stomach lining from damage.

    Peptide
    Semax
    Outcome
    DecreaseGastric mucosal damage from ethanol and stress
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    50 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In albino rats, 5 days of Semax after acetic acid application prevented acetic acid-induced ulcers.

    In plain wordsIn rats, 5 days of Semax after acid was applied to the stomach lining prevented ulcers.

    Peptide
    Semax
    Outcome
    DecreaseAcetic acid-induced gastric ulcers (prevention)
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In albino rats, 5 days of Semax after acetic acid application promoted ulcer healing.

    In plain wordsIn rats, 5 days of Semax after acid was applied to the stomach lining helped ulcers heal.

    Peptide
    Semax
    Outcome
    IncreaseHealing of acetic acid-induced gastric ulcers
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In albino rats, the antiulcer effects of Semax were comparable with those of Pro-Gly-Pro at 1 mg/kg.

    In plain wordsIn rats, Semax protected against ulcers about as well as the tripeptide Pro-Gly-Pro.

    Peptide
    Semax
    Outcome
    No significant changeAntiulcer effect compared with Pro-Gly-Pro
    Study

    ratn: not reported in source

    Comparator
    Pro-Gly-Pro 1 mg/kg
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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