In keloid-producing human fibroblasts, copper tripeptide reduced TGF-beta1 secretion at 24 hours compared with vehicle controls (P<.05).
In plain wordsIn cells, keloid-producing skin fibroblasts treated with copper tripeptide released less TGF-beta1 than control cells.
- Peptide
- GHK-Cu
- Outcome
- DecreaseTGF-beta1 secretion by keloid-producing fibroblasts at 24 hours
- Study
humann: not reported in source
Primary dermal fibroblasts from patient facial skin, serum-free- Comparator
- Vehicle control
- Outcome group
- Wound healing · Skin and wound
- Studied dose
- 1 x 10 (-9) mol/L · 24 hoursAs given in this study (human).
Source sentences
Keloid-producing fibroblasts treated with copper tripeptide secreted less TGF-beta1 than did controls at 24 hours (P<.05); a similar trend was observed in normal fibroblasts.
2 context sentences(design, population, supporting numbers)
Primary cell lines were established from patient facial skin samples obtained during surgery and plated in serum-free media.
At 0 hour, copper tripeptide (1 x 10 (-9) mol/L), tretinoin (1 x 10 (-5) mol/L), or appropriate control vehicle was added.