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Study · Animal study (in vivo) · goat · 2001

6 results

Plasma growth hormone (GH) responses after administration of the peptidergic GH secretagogue KP102 into the oral cavity, rumen, abomasum and duodenum in adult goats.

Hashizume T, Tanabe Y, Ohtsuki K, Mori A, Matsumoto N, Hara S

Domestic animal endocrinology1 Jan 2001Cited by 5 (Europe PMC)

PMID11164332 (opens in a new tab)DOI10.1016/s0739-7240(00)00087-4 (opens in a new tab)PepBankPUB-11164332
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult goats, GH levels were significantly elevated from 20 min to 60 min after KP102 (GHRP‑2) was given into the oral cavity.

    In plain wordsIn adult goats, GHRP‑2 placed in the mouth raised growth hormone for about an hour.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH after KP102 into the oral cavity
    Study

    goatn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 mg/kg BW · oral cavityAs given in this study (goat).

    Source sentences

    Summary
    The GH levels were significantly elevated at 20 min after administration of KP102 into the oral cavity, and plasma concentrations of GH remained significantly elevated until 60 min (P < 0.05).
    1 context sentence
    Summary · context
    Five mg/kg body weight (BW) of KP102 dissolved in 9 ml of saline were administered into the oral cavity, rumen, omasum and duodenum of adult goats, and GH release after administration of KP102 was examined.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult goats, GH levels after KP102 into the abomasum were variable but significantly higher than controls after 120 to 150 min.

    In plain wordsIn adult goats, GHRP‑2 placed in the fourth stomach gave variable growth hormone levels, higher than controls after about two hours.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH after KP102 into the abomasum
    Study

    goatn: not reported in source

    Comparator
    Controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 mg/kg BW · abomasumAs given in this study (goat).

    Source sentences

    Summary
    The GH levels after administration of KP102 into the abomasum were variable. However, the GH level tended to increase within 30 min after administration, and were significantly higher than those of controls after 120 to 150 min (P < 0.05).
    1 context sentence
    Summary · context
    Five mg/kg body weight (BW) of KP102 dissolved in 9 ml of saline were administered into the oral cavity, rumen, omasum and duodenum of adult goats, and GH release after administration of KP102 was examined.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult goats, GH levels were significantly elevated from 40 min to 140 min after KP102 was given into the duodenum.

    In plain wordsIn adult goats, GHRP‑2 placed in the first part of the small intestine raised growth hormone for over an hour.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH after KP102 into the duodenum
    Study

    goatn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 mg/kg BW · duodenumAs given in this study (goat).

    Source sentences

    Summary
    The GH levels after administration of KP102 into the duodenum were significantly elevated at 40 min after administration, and plasma concentrations of GH remained significantly elevated until 140 min (P < 0.05).
    1 context sentence
    Summary · context
    Five mg/kg body weight (BW) of KP102 dissolved in 9 ml of saline were administered into the oral cavity, rumen, omasum and duodenum of adult goats, and GH release after administration of KP102 was examined.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult goats, KP102 given into the rumen failed to stimulate GH release.

    In plain wordsIn adult goats, GHRP‑2 placed in the rumen did not raise growth hormone.

    Peptide
    GHRP-2
    Outcome
    No significant changePlasma GH after KP102 into the rumen
    Study

    goatn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 mg/kg BW · rumenAs given in this study (goat).

    Source sentences

    Summary
    The administration of KP102 into the rumen failed to stimulate GH release.
    1 context sentence
    Summary · context
    Five mg/kg body weight (BW) of KP102 dissolved in 9 ml of saline were administered into the oral cavity, rumen, omasum and duodenum of adult goats, and GH release after administration of KP102 was examined.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In adult goats, the GH response curve (AUC) after KP102 into the abomasum or duodenum was 2.2-fold greater than after administration into the oral cavity.

    In plain wordsIn adult goats, GHRP‑2 placed in the fourth stomach or small intestine gave a 2.2 times larger growth hormone response than placed in the mouth.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC after KP102 into abomasum or duodenum versus oral cavity
    Study

    goatn: not reported in source

    Comparator
    Oral cavity administration
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 mg/kg BW · abomasum or duodenumAs given in this study (goat).

    Measurements

    GH AUC ratio
    2.2 fold
    abomasum or duodenum versus oral cavity

    Source sentences

    Summary
    The GH response curves (AUC) produced after administration of KP102 into the abomasum or duodenum were 2.2-fold greater than those for after administration into the oral cavity (P < 0.05).
    1 context sentence
    Summary · context
    Five mg/kg body weight (BW) of KP102 dissolved in 9 ml of saline were administered into the oral cavity, rumen, omasum and duodenum of adult goats, and GH release after administration of KP102 was examined.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In adult goats, oral KP102 as powder, not dissolved in 9 ml of saline, failed to stimulate GH release.

    In plain wordsIn adult goats, GHRP‑2 given by mouth as a dry powder did not raise growth hormone.

    Peptide
    GHRP-2
    Outcome
    No significant changePlasma GH after KP102 powder, not dissolved in saline
    Study

    goatn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 mg/kg BW · oral (powder)As given in this study (goat).

    Source sentences

    Summary
    The oral administration of 5 mg/kg BW of KP102 in the powder state, not dissolved in 9 ml of saline, failed to stimulate GH release.
    1 context sentence
    Summary · context
    Five mg/kg body weight (BW) of KP102 dissolved in 9 ml of saline were administered into the oral cavity, rumen, omasum and duodenum of adult goats, and GH release after administration of KP102 was examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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