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Study · Animal study (in vivo) · swine · 2001

8 results

Effects of the administration of growth hormone-releasing peptide-2 (GHRP-2) orally by gavage and in feed on growth hormone release in swine.

Phung LT, Sasaki A, Lee HG, Vega RA, Matsunaga N, Hidaka S, Kuwayama H, Hidari H

Domestic animal endocrinology1 Jan 2001Cited by 2 (Europe PMC)

PMID11164330 (opens in a new tab)DOI10.1016/s0739-7240(00)00085-0 (opens in a new tab)PepBankPUB-11164330
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, oral GHRP‑2 by gavage stimulated dose-related increases in peak GH concentrations, returning to basal by 120 min.

    In plain wordsIn pigs, GHRP‑2 given by mouth raised peak growth hormone, with bigger doses giving bigger rises.

    Peptide
    GHRP-2
    Outcome
    IncreasePeak GH concentration after oral gavage, dose-related
    Study

    swinen = 6

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1, 4.5 and 9 mg/kg BW · oral gavage · single bolusAs given in this study (swine).

    Source sentences

    Summary
    Orally administered GHRP-2 stimulated dose-related increases in peak concentrations of GH, with a return to basal by 120 min.
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, peak GH concentrations after oral GHRP‑2 by gavage were higher than in saline controls.

    In plain wordsIn pigs, peak growth hormone after GHRP‑2 by mouth was higher than after saline.

    Peptide
    GHRP-2
    Outcome
    IncreasePeak GH concentration after oral gavage versus saline
    Study

    swinen = 6

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1, 4.5 and 9 mg/kg BW · oral gavage · single bolusAs given in this study (swine).

    Source sentences

    Summary
    After administering GHRP-2 orally, peak concentrations of GH and areas under the GH response curves (GH AUCs) for 180 min were higher (P < 0.05) than those in saline controls.
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, the 180-min GH area under the curve after oral GHRP‑2 by gavage was higher than in saline controls.

    In plain wordsIn pigs, total growth hormone over three hours after GHRP‑2 by mouth was higher than after saline.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC for 180 min after oral gavage versus saline
    Study

    swinen = 6

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1, 4.5 and 9 mg/kg BW · oral gavage · single bolusAs given in this study (swine).

    Source sentences

    Summary
    After administering GHRP-2 orally, peak concentrations of GH and areas under the GH response curves (GH AUCs) for 180 min were higher (P < 0.05) than those in saline controls.
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, GHRP‑2 at 1 mg/kg BW in feed failed to stimulate GH release.

    In plain wordsIn pigs, the lowest GHRP‑2 dose in feed did not raise growth hormone.

    Peptide
    GHRP-2
    Outcome
    No significant changePlasma GH with 1 mg/kg BW GHRP-2 in feed
    Study

    swinen = 6

    Comparator
    Control feed
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 mg/kg BW · oral, in feed · 3 daysAs given in this study (swine).

    Source sentences

    Summary
    Administration of 1 mg/kg BW GHRP-2 to swine in feed failed to stimulate the release of GH
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, GHRP‑2 at 4.5 and 9 mg/kg BW in feed significantly increased plasma GH after the initial and final treatments on Days 1 and 3.

    In plain wordsIn pigs, higher GHRP‑2 doses in feed raised growth hormone on the first and third days.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH with 4.5 and 9 mg/kg BW GHRP-2 in feed
    Study

    swinen = 6

    Comparator
    Control feed
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    4.5 and 9 mg/kg BW · oral, in feed · 3 daysAs given in this study (swine).

    Source sentences

    Summary
    GHRP-2 at doses of 4.5 and 9 mg/kg BW significantly (P < 0.05) increased plasma concentrations of GH after initial and final treatments at 0900 hr on Days 1 and 3 of treatment, respectively.
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, peak GH concentrations after the initial and final treatments with GHRP‑2 in feed at 4.5 and 9 mg/kg BW were higher than in controls.

    In plain wordsIn pigs, peak growth hormone after GHRP‑2 in feed at the two higher doses was higher than in controls.

    Peptide
    GHRP-2
    Outcome
    IncreasePeak GH concentration with GHRP-2 in feed versus controls
    Study

    swinen = 6

    Comparator
    Control feed
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    4.5 and 9 mg/kg BW · oral, in feed · 3 daysAs given in this study (swine).

    Source sentences

    Summary
    Peak concentrations of GH and GH AUCs for 180 min after the initial and final treatments in the 4.5 and 9 mg/kg BW GHRP-2-treated swine were higher (P < 0.05) than those in controls.
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, the 180-min GH area under the curve after GHRP‑2 in feed at 4.5 and 9 mg/kg BW was higher than in controls.

    In plain wordsIn pigs, total growth hormone over three hours after GHRP‑2 in feed at the two higher doses was higher than in controls.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC for 180 min with GHRP-2 in feed versus controls
    Study

    swinen = 6

    Comparator
    Control feed
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    4.5 and 9 mg/kg BW · oral, in feed · 3 daysAs given in this study (swine).

    Source sentences

    Summary
    Peak concentrations of GH and GH AUCs for 180 min after the initial and final treatments in the 4.5 and 9 mg/kg BW GHRP-2-treated swine were higher (P < 0.05) than those in controls.
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In castrated male swine, GH responses to GHRP‑2 in feed at 4.5 and 9 mg/kg BW were maintained after 3 days of treatment.

    In plain wordsIn pigs, the growth hormone response to GHRP‑2 in feed was still there after three days.

    Peptide
    GHRP-2
    Outcome
    No significant changeMaintenance of GH response after 3 days of GHRP-2 in feed
    Study

    swinen = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    4.5 and 9 mg/kg BW · oral, in feed · 3 daysAs given in this study (swine).

    Source sentences

    Summary
    After 3 d of treatment with GHRP-2 in feed at doses of 4.5 and 9 mg/kg BW, GH responses to the peptide were maintained.
    2 context sentences
    Summary · context
    In the first experiment, saline or GHRP-2 at doses of 1, 4.5 and 9 mg/kg body weight (BW) was dissolved in 15 ml saline and administered orally as a bolus by gavage to cross-bred castrated male swine (n = 6).
    Summary · context
    In Experiment 2, GHRP-2 at doses of 0 (served as control), 1, 4.5 and 9 mg/kg BW was mixed in 150 g of feed and offered to cross-bred castrated male swine (n = 6) at 0900 hr and 1700 hr daily for a 3-d period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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