Skip to content

Study · Animal study (in vivo) · mouse · 2001

10 results

Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice.

Anisimov VN, Khavinson VK, Mikhalski AI, Yashin AI

Mechanisms of ageing and development1 Jan 2001Cited by 30 (Europe PMC)

PMID11163623 (opens in a new tab)DOI10.1016/s0047-6374(00)00184-6 (opens in a new tab)PepBankPUB-11163623
Publisher pagePubMedAsk about this study
Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, the pineal tetrapeptide Ala-Glu-Asp-Gly did not modify food consumption.

    In plain wordsIn mice, the pineal peptide did not change how much food the animals ate.

    Peptide
    Epitalon
    Outcome
    No significant changeFood consumption
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    The pineal peptide treatment was failed to modify the food consumption and physical strength of mice
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, the pineal tetrapeptide Ala-Glu-Asp-Gly did not modify physical strength.

    In plain wordsIn mice, the pineal peptide did not change physical strength.

    Peptide
    Epitalon
    Outcome
    No significant changePhysical strength
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Exercise and physical function · Whole body
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    The pineal peptide treatment was failed to modify the food consumption and physical strength of mice
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by an increase in body weight.

    In plain wordsIn mice, the pineal peptide treatment was followed by higher body weight.

    Peptide
    Epitalon
    Outcome
    IncreaseBody weight
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    increase in the body weight
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by an increase in mean survival.

    In plain wordsIn mice, the pineal peptide treatment was followed by longer average survival than saline.

    Peptide
    Epitalon
    Outcome
    IncreaseMean survival
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Measurements

    Mean survival increase
    5.3%
    pineal peptide

    Source sentences

    Summary
    mean survival (by 5.3%, P<0.05)
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by an increase in maximum lifespan.

    In plain wordsIn mice, the pineal peptide treatment was followed by a longer maximum lifespan than saline.

    Peptide
    Epitalon
    Outcome
    IncreaseMaximum lifespan
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Measurements

    Maximum lifespan increase
    10 months
    pineal peptide

    Source sentences

    Summary
    maximum (by 10 months)
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by a slowing of the ageing of estrus function.

    In plain wordsIn mice, the pineal peptide treatment was followed by slower ageing of the estrus cycle.

    Peptide
    Epitalon
    Outcome
    DecreaseAgeing of estrus function
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    slow down of the ageing of estrus function
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by a decrease in body temperature.

    In plain wordsIn mice, the pineal peptide treatment was followed by lower body temperature.

    Peptide
    Epitalon
    Outcome
    DecreaseBody temperature
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Aging markers · Whole body
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    decrease in body temperature
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by a decrease in physical activity.

    In plain wordsIn mice, the pineal peptide treatment was followed by lower physical activity.

    Peptide
    Epitalon
    Outcome
    DecreasePhysical activity
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Exercise and physical function · Whole body
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    decrease in body temperature, physical activity
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by a decrease in free radical processes.

    In plain wordsIn mice, the pineal peptide treatment was followed by lower free radical activity.

    Peptide
    Epitalon
    Outcome
    DecreaseFree radical processes
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    decrease in body temperature, physical activity, free radical processes
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In female CBA mice, treatment with the pineal tetrapeptide Ala-Glu-Asp-Gly was followed by a decrease in spontaneous tumor incidence, mainly lung adenomas.

    In plain wordsIn mice, the pineal peptide treatment was followed by fewer spontaneous tumors, mainly lung adenomas.

    Peptide
    Epitalon
    Outcome
    DecreaseSpontaneous tumor incidence
    Study

    mousen: not reported in source

    Female CBA mice
    Comparator
    Saline
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1 microg/animal · subcutaneous · monthly for five consecutive days from the age of 6 months until natural deathAs given in this study (mouse).

    Source sentences

    Summary
    decrease in body temperature, physical activity, free radical processes and spontaneous tumor incidence (mainly, lung adenomas)
    1 context sentence
    Summary · context
    Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the age of 6 months until natural death.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.