In cultured endothelial cells, enclomiphene inhibited the volume-regulated anion channel similarly to racemic clomiphene.
In plain wordsIn cells, enclomiphene blocked the volume-regulated anion channel similarly to racemic clomiphene.
- Peptide
- Enclomiphene
- Outcome
- No significant changeVolume-regulated anion channel inhibition
- Study
n: not reported in source
cultured pulmonary artery endothelial cells- Comparator
- racemic clomiphene
- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
The inhibition induced by the pure enantiomers of clomiphene, zuclomiphene and enclomiphene, was not different from that of the racemic mixture, indicating that the interaction between clomiphene and VRAC is not stereoselective.
1 context sentence(design, population, supporting numbers)
We have used the whole-cell patch clamp technique to study the effect of the partial anti-oestrogens clomiphene and nafoxidine, the pure anti-oestrogens ICI 182,780 and RU 58,668 and the oestrogen ss-estradiol, on the volume-regulated anion channel (VRAC) in cultured pulmonary artery endothelial (CPAE) cells.