Octreotide in the treatment of thoracic duct injuries.

Markham KM, Glover JL, Welsh RJ, Lucas RJ, Bendick PJ

The American surgeon1 Dec 2000Cited by 58 (Europe PMC)

PMID11149591DOI10.1177/000313480006601215PepBankPUB-11149591

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In dogs with thoracic duct transection, octreotide shortened fistula closure time to 3.5+/-1.3 versus 7.8+/-1.0 days with saline (P = 0.0037).
In plain wordsIn dogs with thoracic duct injury, octreotide shortened fistula closure time compared with saline.
Peptide
Octreotide
Outcome
DecreaseTime to fistula closure
Study
dogn = 8
Thoracic duct transection
Comparator
Saline control
Outcome group
Wound healing · Skin and wound
Studied dose
3 microg/kg three times per dayAs given in this study (dog).
Source sentences
Summary
Treated dogs achieved fistula closure significantly faster than controls: 3.5+/-1.3 days versus 7.8+/-1.0 days (P = 0.0037).
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of octreotide in treating thoracic duct transection in a canine model.
Summary · context
After wound closure dogs were randomized to a control group (n = 4) receiving sham injections of saline subcutaneously three times per day, or a treatment group (n = 4) given 3 microg/kg octreotide three times per day.
Report a problemFND-1114959101
02AnimalAnimal study (in vivo)Efficacy outcome
In dogs with thoracic duct transection, drainage was equivalent with octreotide and saline on surgery day and postoperative day one.
In plain wordsIn dogs, drainage was similar with octreotide and saline on surgery day and the next day.
Peptide
Octreotide
Outcome
No significant changeDrain output on operation day and postoperative day one
Study
dogn = 8
Thoracic duct transection
Comparator
Saline control
Outcome group
Wound healing · Skin and wound
Studied dose
3 microg/kg three times per dayAs given in this study (dog).
Source sentences
Summary
Whereas equivalent amounts of drainage occurred on the day of surgery and on postoperative day one in both groups,
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of octreotide in treating thoracic duct transection in a canine model.
Summary · context
After wound closure dogs were randomized to a control group (n = 4) receiving sham injections of saline subcutaneously three times per day, or a treatment group (n = 4) given 3 microg/kg octreotide three times per day.
Report a problemFND-1114959102
03AnimalAnimal study (in vivo)Efficacy outcome
In dogs, octreotide reduced drainage on postoperative day 2 to 63+/-69 versus 195+/-79 ml with saline (P = 0.046), persisting through day 5.
In plain wordsIn dogs, octreotide reduced drainage compared with saline from postoperative day 2 through day 5.
Peptide
Octreotide
Outcome
DecreasePostoperative drainage
Study
dogn = 8
Thoracic duct transection
Comparator
Saline control
Outcome group
Wound healing · Skin and wound
Studied dose
3 microg/kg three times per dayAs given in this study (dog).
Source sentences
Summary
by postoperative day 2 the treatment group had significantly less drainage over 24 hours: 63+/-69 ml versus 195+/-79 ml (P = 0.046); this significant difference persisted through postoperative day 5 when drainage began to decrease in the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of octreotide in treating thoracic duct transection in a canine model.
Summary · context
After wound closure dogs were randomized to a control group (n = 4) receiving sham injections of saline subcutaneously three times per day, or a treatment group (n = 4) given 3 microg/kg octreotide three times per day.
Report a problemFND-1114959103
04AnimalAnimal study (in vivo)Activity measurement
In dogs, drainage cholesterol did not differ significantly between octreotide and saline at any time point.
In plain wordsIn dogs, drainage cholesterol did not differ significantly between octreotide and saline.
Peptide
Octreotide
Outcome
No significant changeDrainage cholesterol
Study
dogn = 8
Thoracic duct transection
Comparator
Saline control
Outcome group
Lipids · Metabolic and weight
Studied dose
3 microg/kg three times per dayAs given in this study (dog).
Source sentences
Summary
No significant differences between groups were seen in levels of cholesterol, triglycerides, albumin, or protein in the drainage at any time point.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of octreotide in treating thoracic duct transection in a canine model.
Summary · context
After wound closure dogs were randomized to a control group (n = 4) receiving sham injections of saline subcutaneously three times per day, or a treatment group (n = 4) given 3 microg/kg octreotide three times per day.
Report a problemFND-1114959104
05AnimalAnimal study (in vivo)Activity measurement
In dogs, drainage triglycerides did not differ significantly between octreotide and saline at any time point.
In plain wordsIn dogs, drainage triglycerides did not differ significantly between octreotide and saline.
Peptide
Octreotide
Outcome
No significant changeDrainage triglycerides
Study
dogn = 8
Thoracic duct transection
Comparator
Saline control
Outcome group
Lipids · Metabolic and weight
Studied dose
3 microg/kg three times per dayAs given in this study (dog).
Source sentences
Summary
No significant differences between groups were seen in levels of cholesterol, triglycerides, albumin, or protein in the drainage at any time point.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of octreotide in treating thoracic duct transection in a canine model.
Summary · context
After wound closure dogs were randomized to a control group (n = 4) receiving sham injections of saline subcutaneously three times per day, or a treatment group (n = 4) given 3 microg/kg octreotide three times per day.
Report a problemFND-1114959105
06AnimalAnimal study (in vivo)Activity measurement
In dogs, drainage albumin did not differ significantly between octreotide and saline at any time point.
In plain wordsIn dogs, drainage albumin did not differ significantly between octreotide and saline.
Peptide
Octreotide
Outcome
No significant changeDrainage albumin
Study
dogn = 8
Thoracic duct transection
Comparator
Saline control
Outcome group
Drainage Composition · Whole body
Studied dose
3 microg/kg three times per dayAs given in this study (dog).
Source sentences
Summary
No significant differences between groups were seen in levels of cholesterol, triglycerides, albumin, or protein in the drainage at any time point.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of octreotide in treating thoracic duct transection in a canine model.
Summary · context
After wound closure dogs were randomized to a control group (n = 4) receiving sham injections of saline subcutaneously three times per day, or a treatment group (n = 4) given 3 microg/kg octreotide three times per day.
Report a problemFND-1114959106
07AnimalAnimal study (in vivo)Activity measurement
In dogs, drainage protein did not differ significantly between octreotide and saline at any time point.
In plain wordsIn dogs, drainage protein did not differ significantly between octreotide and saline.
Peptide
Octreotide
Outcome
No significant changeDrainage protein
Study
dogn = 8
Thoracic duct transection
Comparator
Saline control
Outcome group
Drainage Composition · Whole body
Studied dose
3 microg/kg three times per dayAs given in this study (dog).
Source sentences
Summary
No significant differences between groups were seen in levels of cholesterol, triglycerides, albumin, or protein in the drainage at any time point.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of octreotide in treating thoracic duct transection in a canine model.
Summary · context
After wound closure dogs were randomized to a control group (n = 4) receiving sham injections of saline subcutaneously three times per day, or a treatment group (n = 4) given 3 microg/kg octreotide three times per day.
Report a problemFND-1114959107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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