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Study · Animal study (in vivo) · rat · 2001

4 results

Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner.

Buhl ES, Jessen N, Schmitz O, Pedersen SB, Pedersen O, Holman GD, Lund S

Diabetes1 Jan 2001Cited by 137 (Europe PMC)

PMID11147776 (opens in a new tab)DOI10.2337/diabetes.50.1.12 (opens in a new tab)PepBankPUB-11147776
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, AICAR increased maximally insulin-stimulated epitrochlearis glucose uptake by an average 63%.

    In plain wordsIn rats, AICAR increased insulin-stimulated sugar uptake in epitrochlearis muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEpitrochlearis insulin-stimulated glucose uptake
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    1 mg/g body wt · subcutaneous · 5 daysAs given in this study (rat).

    Measurements

    Glucose uptake increase
    63%
    EPI, average

    Source sentences

    Summary
    Maximally insulin-stimulated (60 nmol/l) glucose uptake was markedly increased in epitrochlearis (EPI) muscle (average 63%, P < 0.001, n = 18-19) and in extensor digitorum longus muscle (average 26%, P < 0.001, n = 26-30).
    1 context sentence
    Summary · context
    To explore whether AICAR also affects insulin-stimulated glucose transport and GLUT4 cell surface content, Wistar rats were subcutaneously injected with AICAR for 5 days in succession (1 mg/g body wt).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, AICAR increased maximally insulin-stimulated EDL glucose uptake by an average 26%.

    In plain wordsIn rats, AICAR increased insulin-stimulated sugar uptake in EDL muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEDL insulin-stimulated glucose uptake
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    1 mg/g body wt · subcutaneous · 5 daysAs given in this study (rat).

    Measurements

    Glucose uptake increase
    26%
    EDL, average

    Source sentences

    Summary
    Maximally insulin-stimulated (60 nmol/l) glucose uptake was markedly increased in epitrochlearis (EPI) muscle (average 63%, P < 0.001, n = 18-19) and in extensor digitorum longus muscle (average 26%, P < 0.001, n = 26-30).
    1 context sentence
    Summary · context
    To explore whether AICAR also affects insulin-stimulated glucose transport and GLUT4 cell surface content, Wistar rats were subcutaneously injected with AICAR for 5 days in succession (1 mg/g body wt).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, AICAR did not affect maximally insulin-stimulated soleus glucose transport.

    In plain wordsIn rats, AICAR did not change insulin-stimulated sugar transport in soleus muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeSoleus insulin-stimulated glucose transport
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    1 mg/g body wt · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In contrast, administration of AICAR did not maximally influence insulin-stimulated glucose transport in soleus muscle.
    1 context sentence
    Summary · context
    To explore whether AICAR also affects insulin-stimulated glucose transport and GLUT4 cell surface content, Wistar rats were subcutaneously injected with AICAR for 5 days in succession (1 mg/g body wt).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, AICAR increased insulin-exposed epitrochlearis cell surface GLUT4 by an average 68% versus controls.

    In plain wordsIn rats, AICAR increased muscle surface GLUT4 after insulin exposure compared with controls.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEpitrochlearis cell surface GLUT4
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Comparator
    Controls
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    1 mg/g body wt · subcutaneous · 5 daysAs given in this study (rat).

    Measurements

    Cell surface GLUT4 increase
    68%
    EPI after insulin, average

    Source sentences

    Summary
    showed a concomitant increase (average 68%, P < 0.02) in cell surface GLUT4 content after insulin exposure in AICAR-injected rats when compared with controls.
    1 context sentence
    Summary · context
    To explore whether AICAR also affects insulin-stimulated glucose transport and GLUT4 cell surface content, Wistar rats were subcutaneously injected with AICAR for 5 days in succession (1 mg/g body wt).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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