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Study · Animal study (in vivo) · rat · 2000

7 results

Strong effect of PTH (1-34) on regenerating bone: a time sequence study in rats.

Skripitz R, Andreassen TT, Aspenberg P

Acta orthopaedica Scandinavica1 Dec 2000Cited by 50 (Europe PMC)

PMID11145391 (opens in a new tab)DOI10.1080/000164700317362271 (opens in a new tab)PepBankPUB-11145391
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH slightly increased bone growth distance into the chamber versus vehicle.

    In plain wordsIn rats, PTH slightly increased bone ingrowth distance compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone ingrowth distance
    Study

    ratn = 37

    Rats with tibial titanium bone chambers
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 microg/kg daily · Injection · 2, 4, or 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    The total distance of bone growth into the chamber was slightly increased by PTH.
    1 context sentence
    Summary · context
    To study new bone formation we used a titanium bone chamber, and to study normal remodelling we used the femur and vertebrae from the same animals. One titanium bone chamber was inserted in the proximal tibia of each of 37 rats. The rats were randomly assigned to daily injections of human PTH (1-34)…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH did not affect body weight versus vehicle.

    In plain wordsIn rats, PTH did not affect body weight compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBody weight
    Study

    ratn = 37

    Rats with tibial titanium bone chambers
    Comparator
    Vehicle
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    60 microg/kg daily · Injection · 2, 4, or 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Body weight was not affected, and there was only a minor increase in trabecular density of the vertebral and femoral cancellous bone after 6 weeks.
    1 context sentence
    Summary · context
    To study new bone formation we used a titanium bone chamber, and to study normal remodelling we used the femur and vertebrae from the same animals. One titanium bone chamber was inserted in the proximal tibia of each of 37 rats. The rats were randomly assigned to daily injections of human PTH (1-34)…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH maintained a dense trabecular network throughout the chamber while vehicle controls developed a marrow cavity.

    In plain wordsIn rats, PTH maintained dense chamber trabeculae compared with cavity formation in vehicle controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone chamber trabecular network
    Study

    ratn = 37

    Rats with tibial titanium bone chambers
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 microg/kg daily · Injection · 2, 4, or 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    In the PTH-treated animals, a dense network of bone trabeculae was found in the entire bone chamber at all times.
    2 context sentences
    Summary · context
    In the controls, a marrow cavity formed in the chamber so that the cancellous density decreased from 44% to 24%, and 11% over 2, 4 and 6 weeks.
    Summary · context
    To study new bone formation we used a titanium bone chamber, and to study normal remodelling we used the femur and vertebrae from the same animals. One titanium bone chamber was inserted in the proximal tibia of each of 37 rats. The rats were randomly assigned to daily injections of human PTH (1-34)…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH produced only a minor increase in vertebral cancellous trabecular density versus vehicle.

    In plain wordsIn rats, PTH slightly increased vertebral trabecular density compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseVertebral trabecular density
    Study

    ratn: not reported in source

    Rats with tibial titanium bone chambers
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 microg/kg daily · Injection · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Body weight was not affected, and there was only a minor increase in trabecular density of the vertebral and femoral cancellous bone after 6 weeks.
    2 context sentences
    Summary · context
    To study new bone formation we used a titanium bone chamber, and to study normal remodelling we used the femur and vertebrae from the same animals.
    Summary · context
    The rats were randomly assigned to daily injections of human PTH (1-34) 60 microg/kg) or vehicle control and killed after 2, 4 or 6 weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH produced only a minor increase in femoral cancellous trabecular density versus vehicle.

    In plain wordsIn rats, PTH slightly increased femoral trabecular density compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFemoral trabecular density
    Study

    ratn: not reported in source

    Rats with tibial titanium bone chambers
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 microg/kg daily · Injection · 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Body weight was not affected, and there was only a minor increase in trabecular density of the vertebral and femoral cancellous bone after 6 weeks.
    2 context sentences
    Summary · context
    To study new bone formation we used a titanium bone chamber, and to study normal remodelling we used the femur and vertebrae from the same animals.
    Summary · context
    The rats were randomly assigned to daily injections of human PTH (1-34) 60 microg/kg) or vehicle control and killed after 2, 4 or 6 weeks.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH-treated chamber cancellous density increased across the three assessment times.

    In plain wordsIn rats, chamber bone density was higher at later assessment times during PTH treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone chamber cancellous density
    Study

    ratn: not reported in source

    Rats with tibial titanium bone chambers
    Comparator
    PTH-treated rats assessed at earlier times
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 microg/kg daily · Injection · 2, 4, or 6 weeksAs given in this study (rat).

    Measurements

    Cancellous density
    48%
    2 weeks
    Cancellous density
    60%
    4 weeks
    Cancellous density
    73%
    6 weeks

    Source sentences

    Summary
    The cancellous density increased from 48% to 60%, and 73% at 2, 4 and 6 weeks, respectively.
    3 context sentences
    Summary · context
    In the PTH-treated animals, a dense network of bone trabeculae was found in the entire bone chamber at all times.
    Summary · context
    To study new bone formation we used a titanium bone chamber, and to study normal remodelling we used the femur and vertebrae from the same animals.
    Summary · context
    The rats were randomly assigned to daily injections of human PTH (1-34) 60 microg/kg) or vehicle control and killed after 2, 4 or 6 weeks.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In PTH-treated rats, osteoclastic activity remained present throughout chamber specimens but did not resorb all newly formed bone.

    In plain wordsIn rats treated with PTH, bone-resorbing activity remained present but did not remove all newly formed bone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableOsteoclastic activity in chamber specimens
    Study

    ratn: not reported in source

    Rats with tibial titanium bone chambers
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    60 microg/kg daily · Injection · 2, 4, or 6 weeksAs given in this study (rat).

    Source sentences

    Summary
    Even though osteoclastic activity was present throughout the PTH specimens, it was not sufficient to resorb all newly formed bone.
    2 context sentences
    Summary · context
    To study new bone formation we used a titanium bone chamber, and to study normal remodelling we used the femur and vertebrae from the same animals.
    Summary · context
    The rats were randomly assigned to daily injections of human PTH (1-34) 60 microg/kg) or vehicle control and killed after 2, 4 or 6 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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