Neurotrophic effects of FPF-1070 (Cerebrolysin) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks.

Satou T, Itoh T, Tamai Y, Ohde H, Anderson AJ, Hashimoto S

Journal of neural transmission (Vienna, Austria : 1996)1 Jan 2000Cited by 28 (Europe PMC)

PMID11145001DOI10.1007/s007020070015PepBankPUB-11145001

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In chicken embryo DRG explants, Cerebrolysin significantly promoted neurite outgrowth versus phosphate buffered saline at all examined concentrations.
In plain wordsIn lab tests with chicken embryo ganglia, Cerebrolysin increased DRG nerve growth compared with phosphate buffered saline.
Peptide
Cerebrolysin
Outcome
IncreaseDRG neurite outgrowth versus negative control
Study
chickenn: not reported in source
Embryonic ganglion explant cultures
Comparator
Phosphate buffered saline
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
FPF-1070 significantly promoted neurite outgrowth in DRG and ST neurons at all concentrations examined, in comparison with phosphate buffered saline-treated negative controls
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effect of FPF-1070 (Cerebrolysin) on neurite outgrowth in explant cultures of dorsal root ganglia (DRG), sympathetic trunks (ST), and ciliary ganglia (CG) from 10- to 11-day chicken embryos.
Report a problemFND-1114500101
02LabEx vivo tissueActivity measurement
In chicken embryo sympathetic trunk explants, Cerebrolysin significantly promoted neurite outgrowth versus phosphate buffered saline at all examined concentrations.
In plain wordsIn lab tests with chicken embryo ganglia, Cerebrolysin increased sympathetic nerve growth compared with phosphate buffered saline.
Peptide
Cerebrolysin
Outcome
IncreaseST neurite outgrowth versus negative control
Study
chickenn: not reported in source
Embryonic ganglion explant cultures
Comparator
Phosphate buffered saline
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
FPF-1070 significantly promoted neurite outgrowth in DRG and ST neurons at all concentrations examined, in comparison with phosphate buffered saline-treated negative controls
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effect of FPF-1070 (Cerebrolysin) on neurite outgrowth in explant cultures of dorsal root ganglia (DRG), sympathetic trunks (ST), and ciliary ganglia (CG) from 10- to 11-day chicken embryos.
Report a problemFND-1114500102
03LabEx vivo tissueActivity measurement
In chicken embryo DRG explants, Cerebrolysin's neurite outgrowth effect was less significant than that of nerve growth factor.
In plain wordsIn lab tests with chicken embryo ganglia, Cerebrolysin's DRG nerve growth effect was less significant than nerve growth factor's effect.
Peptide
Cerebrolysin
Outcome
Direction not reportedDRG neurite outgrowth versus NGF
Study
chickenn: not reported in source
Embryonic ganglion explant cultures
Comparator
Nerve growth factor
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
however, this effect on neurite outgrowth was not as significant as that observed for nerve growth factor-treated positive controls on DRG and ST neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effect of FPF-1070 (Cerebrolysin) on neurite outgrowth in explant cultures of dorsal root ganglia (DRG), sympathetic trunks (ST), and ciliary ganglia (CG) from 10- to 11-day chicken embryos.
Report a problemFND-1114500103
04LabEx vivo tissueActivity measurement
In chicken embryo sympathetic trunk explants, Cerebrolysin's neurite outgrowth effect was less significant than that of nerve growth factor.
In plain wordsIn lab tests with chicken embryo ganglia, Cerebrolysin's sympathetic nerve growth effect was less significant than nerve growth factor's effect.
Peptide
Cerebrolysin
Outcome
Direction not reportedST neurite outgrowth versus NGF
Study
chickenn: not reported in source
Embryonic ganglion explant cultures
Comparator
Nerve growth factor
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
however, this effect on neurite outgrowth was not as significant as that observed for nerve growth factor-treated positive controls on DRG and ST neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effect of FPF-1070 (Cerebrolysin) on neurite outgrowth in explant cultures of dorsal root ganglia (DRG), sympathetic trunks (ST), and ciliary ganglia (CG) from 10- to 11-day chicken embryos.
Report a problemFND-1114500104
05LabEx vivo tissueActivity measurement
In chicken embryo DRG explants, Cerebrolysin showed an inverted U relationship between concentration and neurite outgrowth effectiveness.
In plain wordsIn lab tests with chicken embryo ganglia, Cerebrolysin's DRG nerve growth effect followed an inverted U concentration relationship.
Peptide
Cerebrolysin
Outcome
MixedDRG concentration-effect relationship
Study
chickenn: not reported in source
Embryonic ganglion explant cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Additionally, FPF-1070 exhibited an inverted U relationship between concentration and effectiveness in DRG and ST neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effect of FPF-1070 (Cerebrolysin) on neurite outgrowth in explant cultures of dorsal root ganglia (DRG), sympathetic trunks (ST), and ciliary ganglia (CG) from 10- to 11-day chicken embryos.
Report a problemFND-1114500105
06LabEx vivo tissueActivity measurement
In chicken embryo sympathetic trunk explants, Cerebrolysin showed an inverted U relationship between concentration and neurite outgrowth effectiveness.
In plain wordsIn lab tests with chicken embryo ganglia, Cerebrolysin's sympathetic nerve growth effect followed an inverted U concentration relationship.
Peptide
Cerebrolysin
Outcome
MixedST concentration-effect relationship
Study
chickenn: not reported in source
Embryonic ganglion explant cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Additionally, FPF-1070 exhibited an inverted U relationship between concentration and effectiveness in DRG and ST neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effect of FPF-1070 (Cerebrolysin) on neurite outgrowth in explant cultures of dorsal root ganglia (DRG), sympathetic trunks (ST), and ciliary ganglia (CG) from 10- to 11-day chicken embryos.
Report a problemFND-1114500106
07LabEx vivo tissueActivity measurement
In chicken embryo ciliary ganglion explants, Cerebrolysin did not affect neurite outgrowth.
In plain wordsIn lab tests with chicken embryo ganglia, Cerebrolysin did not change ciliary nerve growth.
Peptide
Cerebrolysin
Outcome
No significant changeCG neurite outgrowth
Study
chickenn: not reported in source
Embryonic ganglion explant cultures
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In contrast, FPF-1070 did not affect neurite outgrowth in CG neurons
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effect of FPF-1070 (Cerebrolysin) on neurite outgrowth in explant cultures of dorsal root ganglia (DRG), sympathetic trunks (ST), and ciliary ganglia (CG) from 10- to 11-day chicken embryos.
Report a problemFND-1114500107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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